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Magnetoencephalography localizing spike sources of atypical benign partial epilepsy

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Title: Magnetoencephalography localizing spike sources of atypical benign partial epilepsy
Authors: Shiraishi, Hideaki Browse this author →KAKEN DB
Haginoya, Kazuhiro Browse this author
Nakagawa, Eiji Browse this author
Saitoh, Shinji Browse this author
Kaneko, Yutaka Browse this author
Nakasato, Nobukazu Browse this author
Chan, Derrick Browse this author
Otsubo, Hiroshi Browse this author
Keywords: Epileptic negative myoclonus
Focal seizure
Atypical absence
Centro-temporal spike
Continuous spike and waves during sleep
Secondary bilateral synchrony
Issue Date: Jan-2014
Publisher: Elsevier science bv
Journal Title: Brain & development
Volume: 36
Issue: 1
Start Page: 21
End Page: 27
Publisher DOI: 10.1016/j.braindev.2012.12.011
PMID: 23384398
Abstract: Rationale: Atypical benign partial epilepsy (ABPE) is characterized by centro-temporal electroencephalography (EEG) spikes, continuous spike and waves during sleep (CSWS), and multiple seizure types including epileptic negative myoclonus (ENM), but not tonic seizures. This study evaluated the localization of magnetoencephalography (MEG) spike sources (MEGSSs) to investigate the clinical features and mechanism underlying ABPE. Methods: We retrospectively analyzed seizure profiles, scalp video EEG (VEEG) and MEG in ABPE patients. Results: Eighteen ABPE patients were identified (nine girls and nine boys). Seizure onset ranged from 1.3 to 8.8 years (median, 2.9 years). Initial seizures consisted of focal motor seizures (15 patients) and absences/atypical absences (3). Seventeen patients had multiple seizure types including drop attacks (16), focal motor seizures (16), ENM (14), absences/atypical absences (11) and focal myoclonic seizures (10). VEEG showed centro-temporal spikes and CSWS in all patients. Magnetic resonance imaging (MRI) was reported as normal in all patients. MEGSSs were localized over the following regions: both Rolandic and sylvian (8), peri-sylvian (5), peri-Rolandic (4), parieto-occipital (1), bilateral (10) and unilateral (8). All patients were on more than two antiepileptic medications. ENM and absences/atypical absences were controlled in 14 patients treated with adjunctive ethosuximide. Conclusion: MEG localized the source of centro-temporal spikes and CSWS in the Rolandic-sylvian regions. Centro-temporal spikes, Rolandic-sylvian spike sources and focal motor seizures are evidence that ABPE presents with Rolandic-sylvian onset seizures. ABPE is therefore a unique, age-related and localization-related epilepsy with a Rolandic-sylvian epileptic focus plus possible thalamo-cortical epileptic networks in the developing brain of children.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 白石 秀明

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