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The molecular basis of induction and formation of tunneling nanotubes

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Title: The molecular basis of induction and formation of tunneling nanotubes
Authors: Kimura, Shunsuke Browse this author →KAKEN DB
Hase, Koji Browse this author
Ohno, Hiroshi Browse this author
Keywords: Tunneling nanotubes
Rho small GTPase family
exocyst complex
Issue Date: 1-Apr-2014
Publisher: Springer-Verlag
Journal Title: Cell and Tissue Research
Volume: 352
Issue: 1
Start Page: 67
End Page: 76
Publisher DOI: 10.1007/s00441-012-1518-1
PMID: 23229356
Abstract: Tunneling nanotubes (TNTs) and associated structures are recently recognized structures for intercellular communication. They are F-actin containing thin protrusions of the plasma membrane of a cell and allow a direct physical connection to the plasma membranes of remote cells. TNTs and associated structures serve as mediators for intercellular transfer of organelles as well as membrane components and cytoplasmic molecules. Moreover, several pathogens were shown to exploit these structures to spread among cells. Because of their contribution to normal cellular functions and importance in pathological conditions, studies on TNTs and related structures have accelerated over the past few years. These studies have revealed key molecules for their induction and/or formation; HIV Nef and M-Sec can induce the formation of TNTs in coordination with the remodeling of the actin cytoskeleton and vesicle trafficking.
Rights: The final publication is available at
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 俊介

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