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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
The molecular basis of induction and formation of tunneling nanotubes
| Title: | The molecular basis of induction and formation of tunneling nanotubes |
| Authors: | Kimura, Shunsuke Browse this author →KAKEN DB | | Hase, Koji Browse this author | | Ohno, Hiroshi Browse this author |
| Keywords: | Tunneling nanotubes | | M-Sec/TNFaip2/B94 | | Rho small GTPase family | | exocyst complex | | HIV Nef |
| Issue Date: | 1-Apr-2014 |
| Publisher: | Springer-Verlag |
| Journal Title: | Cell and Tissue Research |
| Volume: | 352 |
| Issue: | 1 |
| Start Page: | 67 |
| End Page: | 76 |
| Publisher DOI: | 10.1007/s00441-012-1518-1 |
| PMID: | 23229356 |
| Abstract: | Tunneling nanotubes (TNTs) and associated structures are recently recognized structures for intercellular communication. They are F-actin containing thin protrusions of the plasma membrane of a cell and allow a direct physical connection to the plasma membranes of remote cells. TNTs and associated structures serve as mediators for intercellular transfer of organelles as well as membrane components and cytoplasmic molecules. Moreover, several pathogens were shown to exploit these structures to spread among cells. Because of their contribution to normal cellular functions and importance in pathological conditions, studies on TNTs and related structures have accelerated over the past few years. These studies have revealed key molecules for their induction and/or formation; HIV Nef and M-Sec can induce the formation of TNTs in coordination with the remodeling of the actin cytoskeleton and vesicle trafficking. |
| Rights: | The final publication is available at www.springerlink.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/54969 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 木村 俊介
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