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Comparative study of renin expression in the coagulating glands of C57BL/6 and Balb/c mice

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Title: Comparative study of renin expression in the coagulating glands of C57BL/6 and Balb/c mice
Authors: KON, YASUHIRO1 Browse this author →KAKEN DB
ENDOH, DAIJI Browse this author
FUKAMIZU, AKIYOSHI Browse this author
MURAKAMI, KAZUO Browse this author
HASHIMOTO, YOSHIHARU Browse this author
SUGIMURA, MAKOTO Browse this author
Authors(alt): 昆, 泰寛1
Issue Date: Oct-1992
Publisher: Cambridge University Press
Journal Title: JOURNAL OF ANATOMY
Volume: 181
Start Page: 335
End Page: 343
Abstract: The comparative localisation of renin in the genital organs, especially in the coagulating glands of male mice of the strains C57BL/6 and Balb/c, was investigated using immunocytochemical, immunoelectron microscopical and Northern blot techniques. Dot-like reactions for renin, of varying diameters, were detected immunocytochemically in the epithelial cells of coagulating glands of C57BL/6 mice, but not in those of Balb/c mice. In both strains, many electron dense granules differing in content and morphology were observed in the epithelial cells of the coagulating glands. Crystalline materials were sometimes contained in these granules. Colloidal gold particles indicating the presence of renin were detected in the electron dense granules of C57BL/6 mice, in which they showed a heterogeneous distribution and were especially located on the crystalline structure. No positive reaction was detected in these crystalline structures in Balb/c mice. Renin mRNA was detected in the coagulating glands of both C57BL/6 and Balb/c mice by Northern blot analysis. However, the expression in C57BL/6 coagulating glands was stronger than that in Balb/c. These findings suggest that renin is synthesised and released in the coagulating glands.
Rights: Copyright © 1992 Cambridge University Press
Type: article
URI: http://hdl.handle.net/2115/5507
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 昆 泰寛

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