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Relationship between neutrophil influx and oxidative stress in alveolar space in lipopolysaccharide-induced lung injury

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Title: Relationship between neutrophil influx and oxidative stress in alveolar space in lipopolysaccharide-induced lung injury
Authors: Yoshida, T. Browse this author
Nagai, K. Browse this author →KAKEN DB
Inomata, T. Browse this author
Ito, Y. Browse this author
Betsuyaku, T. Browse this author
Nishimura, M. Browse this author →KAKEN DB
Keywords: Oxidative stress marker
Neutrophil recruitment
Reactive oxygen species
Lung injury model
Issue Date: 15-Jan-2014
Publisher: Elsevier science bv
Journal Title: Respiratory physiology & neurobiology
Volume: 191
Start Page: 75
End Page: 83
Publisher DOI: 10.1016/j.resp.2013.11.008
PMID: 24296043
Abstract: We intratracheally administered lipopolysaccharide (LPS) to ICR mice and then collected BAL fluid and lung tissue to determine whether levels of neutrophils and/or myeloperoxidase (MPO) in bronchoalveolar lavage (BAL) fluid reflect lung tissue damage. Robust neutrophil accumulation into the alveolar space and lung tissue were almost completely abolished at seven days along with oxidative stress markers in the lung. However, lung injury scores and lung wet/dry ratios, as well as MPO and oxidative stress markers in BAL fluid were significantly increased at five and seven days after LPS administration. At later time points, BAL neutrophils generated more MPO activity and ROS than those harvested sooner after LPS administration. Although elevated neutrophil levels in BAL fluid reflected oxidative stress in the lungs, MPO might serve as a useful marker to evaluate damage sustained by epithelial cells over the long term. (C) 2013 Elsevier B.V. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長井 桂

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