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The effect of dopamine on adult hippocampal neurogenesis

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Title: The effect of dopamine on adult hippocampal neurogenesis
Authors: Takamura, Naoki Browse this author
Nakagawa, Shin Browse this author →KAKEN DB
Masuda, Takahiro Browse this author
Boku, Shuken Browse this author →KAKEN DB
Kato, Akiko Browse this author
Song, Ning Browse this author
An, Yan Browse this author
Kitaichi, Yuji Browse this author →KAKEN DB
Inoue, Takeshi Browse this author →KAKEN DB
Koyama, Tsukasa Browse this author →KAKEN DB
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Antidepressant drug
D1-like receptor
D2-like receptor
Progenitor cell
Stem cell
Issue Date: 3-Apr-2014
Publisher: Pergamon-elsevier science ltd
Journal Title: Progress in neuro-psychopharmacology & biological psychiatry
Volume: 50
Start Page: 116
End Page: 124
Publisher DOI: 10.1016/j.pnpbp.2013.12.011
PMID: 24374069
Abstract: Cumulative studies indicated that adult hippocampal neurogenesis might be involved in the action mechanism of antidepressant drugs and/or the pathophysiology of depression. Dopamine (DA) is involved in the regulation of motivation, volition, interest/pleasure, and attention/concentration, all of which are likely to be impaired in depressed patients. Several previous reports suggest that depression may often be accompanied by a relative hypodopaminergic state, and some DA receptor agonists are beneficial effects in the treatment for refractory and bipolar depression. In the present study, to clarify the direct effect of DA on neural progenitor cells, we examined the effect of DA on the proliferation of adult rat dentate gyrus-derived neural precursor cells (ADPs). In addition, we examined the effect of DA receptor agonists on adult rat hippocampal neurogenesis in vivo. Results showed that DA promoted the increase of ADPs via D1-like receptor and D1-like receptor agonist promoted the survival of newborn cells in the adult hippocampus. On the contrary, D2-like receptor agonist did not affect both proliferation and survival. These results suggested that DA might play, at least in part, a role in adult hippocampal neurogenesis via D1-like receptor and the activation of D1-like receptor has a therapeutic potential for depression. (C) 2013 Elsevier Inc. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中川 伸

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