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Effect of the coadministration of citalopram with mirtazapine or atipamezole on rat contextual conditioned fear

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Title: Effect of the coadministration of citalopram with mirtazapine or atipamezole on rat contextual conditioned fear
Authors: Masuda, Takahiro Browse this author
Inoue, Takeshi Browse this author →KAKEN DB
An, Yan Browse this author
Takamura, Naoki Browse this author
Nakagawa, Shin Browse this author →KAKEN DB
Kitaichi, Yuji Browse this author
Koyama, Tsukasa Browse this author →KAKEN DB
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: anxiety
conditioned fear
selective serotonin reuptake inhibitor
Issue Date: 11-Feb-2014
Publisher: Dove medical press ltd
Journal Title: Neuropsychiatric disease and treatment
Volume: 10
Start Page: 289
End Page: 295
Publisher DOI: 10.2147/NDT.S55507
PMID: 24627635
Abstract: Background: Mirtazapine, a noradrenergic and specific serotonergic antidepressant, which blocks the alpha(2)-adrenergic autoreceptors and heteroreceptors, has shown anxiolytic properties in clinical trials and preclinical animal experiments. The addition of mirtazapine to selective serotonin reuptake inhibitors (SSRIs) is clinically suggested to be more effective for anxiety disorders. In this study, we examined the combined effects of mirtazapine and citalopram, an SSRI, on the freezing behavior of rats, which was induced by contextual conditioned fear as an index of anxiety or fear. Methods: Male Sprague Dawley rats individually received footshocks in a shock chamber, and 24 hours later, they were given citalopram and/or mirtazapine injections. One hour after citalopram and 30 minutes after mirtazapine administration, freezing behavior was analyzed in the same shock chamber without shocks. Results: Mirtazapine decreased freezing in a dose-dependent manner, which is consistent with a previous report; it also enhanced an anxiolytic-like effect at a high dose (30 mg/kg) of citalopram. Because mirtazapine blocks alpha(2)-adrenoreceptors, the combined effect of atipamezole, a selective alpha(2) receptor antagonist, with citalopram was also examined. Similar to mirtazapine, atipamezole reduced freezing dose-dependently, but the enhancement of citalopram's effects by atipamezole was not clear when compared with mirtazapine. Conclusion: The present findings suggest that mirtazapine has an anxiolytic-like effect and may enhance the anxiolytic-like effect of SSRIs, but this enhancement may not be explained by its anti-alpha(2) property alone.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井上 猛

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