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Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer.

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Title: Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer.
Authors: Kawamata, Futoshi Browse this author
Kamachi, Hirofumi Browse this author →KAKEN DB
Einama, Takahiro Browse this author
Homma, Shigenori Browse this author
Tahara, Munenori Browse this author
Miyazaki, Masaya Browse this author
Tanaka, Shinya Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Nishihara, Hiroshi Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Todo, Satoru Browse this author →KAKEN DB
Keywords: Mesothelin
Intracellular localization
Luminal membrane
Issue Date: Dec-2012
Publisher: Spandidos Publications
Journal Title: International journal of oncology
Volume: 41
Issue: 6
Start Page: 2109
End Page: 2118
Publisher DOI: 10.3892/ijo.2012.1662
PMID: 23064529
Abstract: Mesothelin is expressed in various types of malignant tumors, and we recently reported that the expression of mesothelin was related to unfavorable patient outcome in pancreatic ductal adenocarcinoma and gastric adenocarcinoma. In this study, we examined the clinicopathological significance of mesothelin expression in extrahepatic bile duct cancer (EHBDCA), especially in terms of its association with the staining pattern. Tissue samples from 61 EHBDCA (16 hilar cholangiocarcinoma, 17 upper bile duct adenocarci-noma, 20 middle bile duct adenocarcinoma and 8 distal bile duct adenocarcinoma) were immunohistochemically examined. The expression levels of mesothelin in tumor cells was classified into the localization of mesothelin in luminal membrane and/or cytoplasm, in addition to high and low according to the staining intensity and proportion as a conventional analysis. 'High-level expression' of mesothelin (47.5%) was statistically correlated with liver metastasis (P=0.013) and poorer patient outcome (P=0.022), while 'luminal membrane positive' of mesothelin (52.5%) was more significantly correlated with liver metastasis (P=0.006), peritoneal metastasis (P=0.024) and unfavorable patient outcome (P=0.017). Moreover, we found that 'cytoplasmic expression' isolated from 'luminal membrane negative' of mesothelin represented the best patient prognosis throughout this study. We describe the expression pattern level of mesothelin, i.e., in luminal membrane or cytoplasm both high and low level, evidently indicate the patient prognosis of EHBDCA, suggesting the pivotal role of mesothelin in cancer promotion depending on its intracellular localization.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西原 広史

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