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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer.
| Title: | Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer. |
| Authors: | Kawamata, Futoshi Browse this author | | Kamachi, Hirofumi Browse this author →KAKEN DB | | Einama, Takahiro Browse this author | | Homma, Shigenori Browse this author | | Tahara, Munenori Browse this author | | Miyazaki, Masaya Browse this author | | Tanaka, Shinya Browse this author →KAKEN DB | | Kamiyama, Toshiya Browse this author →KAKEN DB | | Nishihara, Hiroshi Browse this author →KAKEN DB | | Taketomi, Akinobu Browse this author →KAKEN DB | | Todo, Satoru Browse this author →KAKEN DB |
| Keywords: | Mesothelin | | Intracellular localization | | Luminal membrane | | Expression |
| Issue Date: | Dec-2012 |
| Publisher: | Spandidos Publications |
| Journal Title: | International journal of oncology |
| Volume: | 41 |
| Issue: | 6 |
| Start Page: | 2109 |
| End Page: | 2118 |
| Publisher DOI: | 10.3892/ijo.2012.1662 |
| PMID: | 23064529 |
| Abstract: | Mesothelin is expressed in various types of malignant tumors, and we recently reported that the expression of mesothelin was related to unfavorable patient outcome in pancreatic ductal adenocarcinoma and gastric adenocarcinoma. In this study, we examined the clinicopathological significance of mesothelin expression in extrahepatic bile duct cancer (EHBDCA), especially in terms of its association with the staining pattern. Tissue samples from 61 EHBDCA (16 hilar cholangiocarcinoma, 17 upper bile duct adenocarci-noma, 20 middle bile duct adenocarcinoma and 8 distal bile duct adenocarcinoma) were immunohistochemically examined. The expression levels of mesothelin in tumor cells was classified into the localization of mesothelin in luminal membrane and/or cytoplasm, in addition to high and low according to the staining intensity and proportion as a conventional analysis. 'High-level expression' of mesothelin (47.5%) was statistically correlated with liver metastasis (P=0.013) and poorer patient outcome (P=0.022), while 'luminal membrane positive' of mesothelin (52.5%) was more significantly correlated with liver metastasis (P=0.006), peritoneal metastasis (P=0.024) and unfavorable patient outcome (P=0.017). Moreover, we found that 'cytoplasmic expression' isolated from 'luminal membrane negative' of mesothelin represented the best patient prognosis throughout this study. We describe the expression pattern level of mesothelin, i.e., in luminal membrane or cytoplasm both high and low level, evidently indicate the patient prognosis of EHBDCA, suggesting the pivotal role of mesothelin in cancer promotion depending on its intracellular localization. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/55137 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 西原 広史
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