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Morphogenetic Study on the Maturation of Osteoblastic Cell as Induced by Inorganic Polyphosphate
This item is licensed under:Creative Commons Attribution 3.0 Unported
| Title: | Morphogenetic Study on the Maturation of Osteoblastic Cell as Induced by Inorganic Polyphosphate |
| Authors: | Tsutsumi, Kaori Browse this author →KAKEN DB | | Saito, Nagahito Browse this author | | Kawazoe, Yumi Browse this author | | Ooi, Hong-Kean Browse this author | | Shiba, Toshikazu Browse this author |
| Issue Date: | Mar-2014 |
| Publisher: | Public library science |
| Journal Title: | Plos one |
| Volume: | 9 |
| Issue: | 2 |
| Start Page: | e86834 |
| Publisher DOI: | 10.1371/journal.pone.0086834 |
| Abstract: | Since inorganic polyphosphates [poly(P)] have an activity to induce bone differenciation in vitro and in vivo, we examined an effect of poly(P) on organelle by light microscopy and electron microscopy in Murine MC3T3-E1 osteoblastic cells. The MC3T3-E1 cells were ultrastructurally observed to possess morphological characteristics of osteoblasts. Cells cultured with poly(P) were strongly stained with an anti-collagen type I antibody but not in those cultured without poly(P). Ultrastructural analysis of cells cultured with poly(P) revealed a well-developed Golgi apparatus, swollen and elongated rough endoplasmic reticulum, large mitochondria and many coated pits. Since MC3T3-E1 cells can be transformed from a resting phase to an active blastic cell phase after supplementation with poly(P), it implies that poly(P) can be an effective material for bone regeneration. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/55177 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 堤 香織
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