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Morphogenetic Study on the Maturation of Osteoblastic Cell as Induced by Inorganic Polyphosphate

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Title: Morphogenetic Study on the Maturation of Osteoblastic Cell as Induced by Inorganic Polyphosphate
Authors: Tsutsumi, Kaori Browse this author →KAKEN DB
Saito, Nagahito Browse this author
Kawazoe, Yumi Browse this author
Ooi, Hong-Kean Browse this author
Shiba, Toshikazu Browse this author
Issue Date: Feb-2014
Publisher: Public library science
Journal Title: Plos one
Volume: 9
Issue: 2
Publisher DOI: 10.1371/journal.pone.0086834
Abstract: Since inorganic polyphosphates [poly(P)] have an activity to induce bone differenciation in vitro and in vivo, we examined an effect of poly(P) on organelle by light microscopy and electron microscopy in Murine MC3T3-E1 osteoblastic cells. The MC3T3-E1 cells were ultrastructurally observed to possess morphological characteristics of osteoblasts. Cells cultured with poly(P) were strongly stained with an anti-collagen type I antibody but not in those cultured without poly(P). Ultrastructural analysis of cells cultured with poly(P) revealed a well-developed Golgi apparatus, swollen and elongated rough endoplasmic reticulum, large mitochondria and many coated pits. Since MC3T3-E1 cells can be transformed from a resting phase to an active blastic cell phase after supplementation with poly(P), it implies that poly(P) can be an effective material for bone regeneration.
Type: article
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 堤 香織

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