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Lipoxygenase inhibitors derived from marine macroalgae

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/55254

Title: Lipoxygenase inhibitors derived from marine macroalgae
Authors: Kurihara, Hideyuki Browse this author →KAKEN DB
Kagawa, Yoshio Browse this author
Konno, Remi Browse this author
Kim, Sang Moo Browse this author
Takahashi, Koretaro Browse this author →KAKEN DB
Keywords: Lipoxygenase
Inhibitor
Sargassum thunbergii
Alkapolyene
Odonthalia corymbifera
Pheophytin a
Issue Date: 1-Mar-2014
Publisher: Pergamon-elsevier science ltd
Journal Title: Bioorganic & medicinal chemistry letters
Volume: 24
Issue: 5
Start Page: 1383
End Page: 1385
Publisher DOI: 10.1016/j.bmcl.2014.01.046
PMID: 24495846
Abstract: The solvent extracts from the algae Sargassum thunbergii (Sargassaceae) and Odonthalia corymbifera (Rhodomelaceae) were subjected to soybean lipoxygenase inhibitory screening. Two hydrophobic inhibitors were obtained from the extracts of S. thunbergii through inhibitory assay-guided fractionation. The inhibitors were identified as known exo-methylenic alkapolyenes (6Z, 9Z, 12Z, 15Z)-1,6,9,12,15-henicosapentaene (1) and (6Z, 9Z, 12Z, 15Z, 18Z)-1,6,9,12,15,18-henicosahexaene (2). The alkapolyenes 1 and 2 showed higher inhibitory activity than the known inhibitor nordihydroguaiaretic acid (NDGA). Pheophytin a (3) was obtained from the extract of O. corymbifera. The inhibitor 3 also showed higher inhibitory activity than NDGA. This is the first report on lipoxygenase inhibition of exo-methylenic alkapolyenes and a chlorophyll a-related substance. (C) 2014 Elsevier Ltd. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/55254
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 栗原 秀幸

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