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Lipoxygenase inhibitors derived from marine macroalgae
Title: | Lipoxygenase inhibitors derived from marine macroalgae |
Authors: | Kurihara, Hideyuki Browse this author →KAKEN DB | Kagawa, Yoshio Browse this author | Konno, Remi Browse this author | Kim, Sang Moo Browse this author | Takahashi, Koretaro Browse this author →KAKEN DB |
Keywords: | Lipoxygenase | Inhibitor | Sargassum thunbergii | Alkapolyene | Odonthalia corymbifera | Pheophytin a |
Issue Date: | 1-Mar-2014 |
Publisher: | Pergamon-elsevier science ltd |
Journal Title: | Bioorganic & medicinal chemistry letters |
Volume: | 24 |
Issue: | 5 |
Start Page: | 1383 |
End Page: | 1385 |
Publisher DOI: | 10.1016/j.bmcl.2014.01.046 |
PMID: | 24495846 |
Abstract: | The solvent extracts from the algae Sargassum thunbergii (Sargassaceae) and Odonthalia corymbifera (Rhodomelaceae) were subjected to soybean lipoxygenase inhibitory screening. Two hydrophobic inhibitors were obtained from the extracts of S. thunbergii through inhibitory assay-guided fractionation. The inhibitors were identified as known exo-methylenic alkapolyenes (6Z, 9Z, 12Z, 15Z)-1,6,9,12,15-henicosapentaene (1) and (6Z, 9Z, 12Z, 15Z, 18Z)-1,6,9,12,15,18-henicosahexaene (2). The alkapolyenes 1 and 2 showed higher inhibitory activity than the known inhibitor nordihydroguaiaretic acid (NDGA). Pheophytin a (3) was obtained from the extract of O. corymbifera. The inhibitor 3 also showed higher inhibitory activity than NDGA. This is the first report on lipoxygenase inhibition of exo-methylenic alkapolyenes and a chlorophyll a-related substance. (C) 2014 Elsevier Ltd. All rights reserved. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/55254 |
Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 栗原 秀幸
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