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Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/55287

Title: Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles
Authors: Yasui, Hironobu Browse this author →KAKEN DB
Takeuchi, Ryo Browse this author
Nagane, Masaki Browse this author
Meike, Shunsuke Browse this author
Nakamura, Yoshinari Browse this author
Yamamori, Tohru Browse this author →KAKEN DB
Ikenaka, Yoshinori Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Murotani, Hiroki Browse this author
Oishi, Motoi Browse this author →KAKEN DB
Nagasaki, Yukio Browse this author →KAKEN DB
Inanami, Osamu Browse this author →KAKEN DB
Keywords: Apoptosis
DNA repair
Endoplasmic reticulum stress
Gold nanoparticle
Radiation
Issue Date: Mar-2014
Journal Title: Cancer Letters
Volume: 347
Issue: 1
Start Page: 151
End Page: 158
Publisher DOI: 10.1016/j.canlet.2014.02.005
PMID: 24530512
Abstract: High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatment increased the levels of reproductive cell death and apoptosis induced by X-irradiation. GNG accumulated in cytoplasm and increased the expression of endoplasmic reticulum (ER) stress-related protein. GNG suppressed the repair capacity of DNA after X-irradiation by down-regulating DNA repair-related proteins. Our results suggest that GNG radiosensitized cells by enhancing apoptosis and impairing DNA repair capacity via ER stress induction.
Relation: http://www.sciencedirect.com/science/journal/03043835/
Type: article (author version)
URI: http://hdl.handle.net/2115/55287
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 稲波 修

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