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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles
| Title: | Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles |
| Authors: | Yasui, Hironobu Browse this author →KAKEN DB | | Takeuchi, Ryo Browse this author | | Nagane, Masaki Browse this author | | Meike, Shunsuke Browse this author | | Nakamura, Yoshinari Browse this author | | Yamamori, Tohru Browse this author →KAKEN DB | | Ikenaka, Yoshinori Browse this author →KAKEN DB | | Kon, Yasuhiro Browse this author →KAKEN DB | | Murotani, Hiroki Browse this author | | Oishi, Motoi Browse this author →KAKEN DB | | Nagasaki, Yukio Browse this author →KAKEN DB | | Inanami, Osamu Browse this author →KAKEN DB |
| Keywords: | Apoptosis | | DNA repair | | Endoplasmic reticulum stress | | Gold nanoparticle | | Radiation |
| Issue Date: | Mar-2014 |
| Journal Title: | Cancer Letters |
| Volume: | 347 |
| Issue: | 1 |
| Start Page: | 151 |
| End Page: | 158 |
| Publisher DOI: | 10.1016/j.canlet.2014.02.005 |
| PMID: | 24530512 |
| Abstract: | High atomic number molecules, such as gold and platinum, are known to enhance the biological effect of X-irradiation. This study was aimed to determine the radiosensitizing potential of PEGylated nanogel containing gold nanoparticles (GNG) and the cellular mechanism involved. GNG pretreatment increased the levels of reproductive cell death and apoptosis induced by X-irradiation. GNG accumulated in cytoplasm and increased the expression of endoplasmic reticulum (ER) stress-related protein. GNG suppressed the repair capacity of DNA after X-irradiation by down-regulating DNA repair-related proteins. Our results suggest that GNG radiosensitized cells by enhancing apoptosis and impairing DNA repair capacity via ER stress induction. |
| Relation: | http://www.sciencedirect.com/science/journal/03043835/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/55287 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 稲波 修
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