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Bone Marrow Graft-versus-Host Disease : Evaluation of Its Clinical Impact on Disrupted Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/55428

Title: Bone Marrow Graft-versus-Host Disease : Evaluation of Its Clinical Impact on Disrupted Hematopoiesis after Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Shono, Yusuke Browse this author
Shiratori, Souichi Browse this author
Kosugi-Kanaya, Mizuha Browse this author
Ueha, Satoshi Browse this author
Sugita, Junichi Browse this author
Shigematsu, Akio Browse this author
Kondo, Takeshi Browse this author →KAKEN DB
Hashimoto, Daigo Browse this author
Fujimoto, Katsuya Browse this author
Endo, Tomoyuki Browse this author
Nishio, Mitsufumi Browse this author →KAKEN DB
Hashino, Satoshi Browse this author →KAKEN DB
Matsuno, Yoshihiro Browse this author
Matsushima, Kouji Browse this author
Tanaka, Junji Browse this author →KAKEN DB
Imamura, Masahiro Browse this author →KAKEN DB
Teshima, Takanori Browse this author →KAKEN DB
Keywords: Bone marrow graft-versus-host disease (BM GVHD)
Idiopathic cytopenias
Osteoblasts
Issue Date: Apr-2014
Publisher: Elsevier
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 20
Issue: 4
Start Page: 495
End Page: 500
Publisher DOI: 10.1016/j.bbmt.2013.12.568
PMID: 24374213
Abstract: Idiopathic cytopenias are frequently observed in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We have previously reported the effect of graft-versus-host disease (GVHD) on bone marrow (BM) in murine models, indicating that the osteoblast injury mediated by donor T cells was associated with bone marrow suppression and delayed immune reconstitution. In this study, we prospectively evaluated the relevance of these findings in 51 patients. Patients with chronic GVHD manifested the loss of osteoblasts, contributing to cytopenic symptoms (P =.0427 compared with patients without cytopenic symptoms). The loss of osteoblasts was significantly associated with the extensive type of chronic GVHD (P =.012), and flow cytometric analyses revealed lower numbers of CD19(+) B cells and a significantly increased CD4 to CD8 ratio (P.0002) in these patients. Our data, for the first time to our knowledge, summarize the detailed analyses of the effect of GVHD on BM in the clinical allo-HSCT patients. (c) 2014 American Society for Blood and Marrow Transplantation.
Type: article (author version)
URI: http://hdl.handle.net/2115/55428
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 庄野 雄介

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