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Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/5566

Title: Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia
Authors: Hayasaka, Daisuke Browse this author
Ivanov, Leonid Browse this author
Leonova, Galina N Browse this author
Goto, Akiko Browse this author
Yoshii, Kentaro Browse this author →KAKEN DB
Mizutani, Tetsuya Browse this author
Kariwa, Hiroaki Browse this author →KAKEN DB
Takashima, Ikuo8 Browse this author →KAKEN DB
Authors(alt): 高島, 郁夫8
Issue Date: 2001
Publisher: Society for General Microbiology.
Journal Title: Journal of General Virology
Volume: 82
Start Page: 1319
End Page: 1328
Publisher DOI: 10.1099/0022-1317-82-6-1319
Abstract: In this study, tick-borne encephalitis (TBE) viruses from Siberia and far-eastern Asia were characterized in order to determine virus subtype distribution. TBE viruses were isolated from ticks (Ixodes persulcatus) collected in the far-eastern (Khabarovsk and Vladivostok) and Siberian (Irkutsk) regions of Russia in 1999. Phylogenetic analysis showed that isolates formed distinct clusters of far-eastern and Siberian subtypes. There was also a minor difference in antigenicity between the Irkutsk isolates and other TBE virus strains, as demonstrated by the reactivity of monoclonal antibodies. Amino acid alignments of the E gene showed that the Irkutsk isolates had a single amino acid change at position 234 (Q or H); this amino acid position is considered to be a ‘signature’ of Siberian subtype TBE viruses. Strains isolated in Irkutsk also exhibited equivalent or somewhat higher virulence in mice compared with far-eastern TBE virus isolates. All viruses isolated in this study (i.e. far-east Asian and Siberian isolates) have 3' non-coding regions (NCRs) of almost the same length, which contrasts with the various sizes of 3'NCRs of other TBE viruses strains reported previously. The data presented in this study show that the 3'NCR is uniform among TBE viruses isolated from Siberia and far-eastern Asia and that the 3'NCR is essential for TBE virus growth in tick and/or rodent host cells.
Type: article
URI: http://hdl.handle.net/2115/5566
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高島 郁夫

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