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Double network hydrogels from polyzwitterions : high mechanical strength and excellent anti-biofouling properties

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Title: Double network hydrogels from polyzwitterions : high mechanical strength and excellent anti-biofouling properties
Authors: Yin, Haiyan Browse this author
Akasaki, Taigo Browse this author
Sun, Tao Lin Browse this author
Nakajima, Tasuku Browse this author
Kurokawa, Takayuki Browse this author
Nonoyama, Takayuki Browse this author
Taira, Toshio Browse this author
Saruwatari, Yoshiyuki Browse this author
Gong, Jian Ping Browse this author →KAKEN DB
Issue Date: 23-May-2013
Publisher: Royal Society of Chemistry
Journal Title: Journal of Materials Chemistry B
Volume: 1
Issue: 30
Start Page: 3685
End Page: 3693
Publisher DOI: 10.1039/c3tb20324g
Abstract: Polyzwitterionic materials, which have both cationic and anionic groups in the polymeric repeat unit, show excellent anti-biofouling properties and are drawing more attention in the biomedical field. In this study, we have successfully synthesized novel single network hydrogels and double network (DN) hydrogels from the zwitterionic monomer, N-(carboxymethyl)-N,N-dimethyl-2-(methacryloyloxy) ethanaminium, inner salt (CDME). The polyCDME (PCDME) single network hydrogel behaves like a hydrophilic neutral hydrogel and its properties are not sensitive to temperature, pH, or ionic strength over a wide range. DN hydrogels using the poly(2-acrylamido-2-methylpropanesulfonic) (PAMPS) as the first network and PCDME as the second network, having a Young's modulus of 0.2-0.9 MPa, possess excellent mechanical strength (fracture stress: 1.2-1.4 MPa, fracture strain: 2.2-6.0 mm/mm) and toughness (work of extension at fracture: 0.9-2.4 MJ m(-3)) depending on the composition ratio of PCDME to PAMPS. The strength and toughness of the optimized PAMPS/PCDME DN is comparable to the normal PAMPS/PAAm DN hydrogels that use poly(acrylamide) (PAAm) as the second network. By macrophage adhesion test, both the PCDME hydrogels and the PAMPS/PCDME DN hydrogels have shown excellent anti-biofouling properties. These results demonstrate that the PCDME-based DN hydrogels have high potential as a novel soft and wet biomaterial.
Type: article (author version)
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 龔 剣萍 (Gong Jian Ping)

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