HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Effects of campaign for postpartum vaccination on seronegative rate against rubella among Japanese women

This item is licensed under: Creative Commons Attribution 2.0 Generic

Files in This Item:
BMC Infect Dis_14_152.pdf323.56 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/55824

Title: Effects of campaign for postpartum vaccination on seronegative rate against rubella among Japanese women
Authors: Yamada, Takahiro Browse this author →KAKEN DB
Mochizuki, Junko Browse this author
Hanaoka, Masachi Browse this author
Hashimoto, Eriko Browse this author
Ohkuchi, Akihide Browse this author
Ito, Mika Browse this author
Kubo, Takahiko Browse this author
Nakai, Akihito Browse this author
Saito, Shigeru Browse this author
Unno, Nobuya Browse this author
Matsubara, Shigeki Browse this author
Minakami, Hisanori Browse this author →KAKEN DB
Keywords: Congenital rubella syndrome
Outbreak
Vaccine
Issue Date: 21-Mar-2014
Publisher: Biomed Central
Journal Title: BMC infectious Diseases
Volume: 14
Start Page: 152
Publisher DOI: 10.1186/1471-2334-14-152
PMID: 24650141
Abstract: Background: Japan experienced two rubella outbreaks in the past decade (2004 and 2012 - 2013), resulting in 10 and 20 infants with congenital rubella syndrome (CRS), respectively. This study was performed to determine whether the seronegative rate was lower in multiparous women than in primiparous women in Japan. Methods: Hemagglutination inhibition (HI) test results during pregnancy were analyzed retrospectively in 11048 primiparous and 9315 multiparous women who gave birth at six hospitals in northern Japan in the 5-year study period (January 2008 through December 2012). Women with HI titer < 1: 8 were defined as susceptible to rubella. Results: The seronegative rate was significantly lower in multiparous than primiparous women aged 30 - 31 years (2.3% [22/967] vs. 4.5% [66/1454], P = 0.0036), 36 - 37 years (3.4% [55/1601] vs. 5.7% [79/1389], P = 0.0030), and overall women (3.8% [350/9315] aged 34.7 +/- 5.2 vs. 5.4% [597/11048] for 33.2 +/- 5.9, P < 0.001). The susceptible fraction size did not differ largely according to hospital, ranging from 3.5% to 6.3%. Those for each year did not change markedly; 4.5% [150/3369], 5.2% [221/4268], 4.4% [195/4412], 4.6% [186/4056], and 4.6% [195/4258] for 2008, 2009, 2010, 2011, and 2012, respectively. Those for teenagers were consistently high: 22.7% [5/22], 20.7% [6/29], 20.6% [7/34], 13.0% [3/23], and 23.5% [4/17] for 2008, 2009, 2010, 2011, and 2012, respectively. Conclusions: The seronegative rate was significantly lower in multiparous than primiparous women. However, Japanese rubella vaccination programs were insufficient to eliminate CRS.
Rights: http://creativecommons.org/licenses/by/2.0/
Type: article
URI: http://hdl.handle.net/2115/55824
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 山田 崇弘

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 

 - Hokkaido University