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Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice

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Title: Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice
Authors: Nakayama, Yosuke Browse this author
Moriya, Tomohiro Browse this author
Sakai, Fumihiko Browse this author
Ikeda, Noriko Browse this author
Shiozaki, Takuya Browse this author
Hosoya, Tomohiro Browse this author
Nakagawa, Hisako Browse this author
Miyazaki, Tadaaki Browse this author →KAKEN DB
Issue Date: 10-Apr-2014
Publisher: Nature Publishing Group
Journal Title: Scientific Reports
Volume: 4
Start Page: 4638
Publisher DOI: 10.1038/srep04638
PMID: 24717726
Abstract: The Lactobacillus gasseri SBT2055 (LG2055) is a probiotic lactic acid bacterium with properties such as bile tolerance and ability to improve the intestinal environment. In this study, we established that the oral administration of LG2055 exhibits efficacy to protect mice infected with the influenza virus A/PR8. The body weight losses were lower with the LG2055 administration after the PR8 virus infection. At 5 days after the infection, the virus titer was significantly decreased as was the amount of produced IL-6 in the lung tissue, the number of total cells in the bronchoalveolar lavage fluid was reduced by the LG2055 administration. The expression of the Mx1 and Oas1a genes, critical for the viral clearance in the lung tissues was increased by the pre-treatment with LG2055. These findings suggest that the LG2055 administration is effective for the protection against influenza A virus infection by the down-regulation of viral replication through the induction of antiviral genes expression.
Rights: http://creativecommons.org/licenses/by/3.0/
Type: article
URI: http://hdl.handle.net/2115/55893
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 宮崎 忠昭

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