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Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis

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Title: Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis
Authors: Ishikawa, Noemia Kazue Browse this author
Tahara, Satoshi Browse this author
Namatame, Tomohiro Browse this author
Farooq, Afgan Browse this author
Fukushi, Yukiharu Browse this author →KAKEN DB
Keywords: Antimicrobial compound
edible mushroom
Flammulina velutipes
Issue Date: 2014
Publisher: Brazilian Society for Microbiology
Journal Title: Brazilian Journal of Microbiology
Volume: 44
Issue: 4
Start Page: 1285
End Page: 1290
Abstract: Enokipodins A, B, C, and D are antimicrobial sesquiterpenes isolated from the mycelial culture medium of Flammulina velutipes, an edible mushroom. The presence of a quaternary carbon stereo-center on the cyclopentane ring makes enokipodins A-D attractive synthetic targets. In this study, nine different cytochrome P450 inhibitors were used to trap the biosynthetic intermediates of highly oxygenated cuparene-type sesquiterpenes of F. velutipes. Of these, 1-aminobenzotriazole produced three less-highly oxygenated biosynthetic intermediates of enokipodins A-D; these were identified as (S)-(-)-cuparene-1,4-quinone and epimers at C-3 of 6-hydroxy-6-methyl-3-(1,2,2-trimethylcyclopentyl)- 2-cyclohexen-1-one. One of the epimers was found to be a new compound.
Type: article
Appears in Collections:農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 福士 幸治

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