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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Agriculture / Faculty of Agriculture >
Peer-reviewed Journal Articles, etc >
Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis
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| Title: | Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis |
| Authors: | Ishikawa, Noemia Kazue Browse this author | | Tahara, Satoshi Browse this author | | Namatame, Tomohiro Browse this author | | Farooq, Afgan Browse this author | | Fukushi, Yukiharu Browse this author →KAKEN DB |
| Keywords: | Antimicrobial compound | | cuparene-1,4-quinone | | edible mushroom | | enokitake | | Flammulina velutipes |
| Issue Date: | 2014 |
| Publisher: | Brazilian Society for Microbiology |
| Journal Title: | Brazilian Journal of Microbiology |
| Volume: | 44 |
| Issue: | 4 |
| Start Page: | 1285 |
| End Page: | 1290 |
| Abstract: | Enokipodins A, B, C, and D are antimicrobial sesquiterpenes isolated from the mycelial culture medium of Flammulina velutipes, an edible mushroom. The presence of a quaternary carbon stereo-center on the cyclopentane ring makes enokipodins A-D attractive synthetic targets. In this study, nine different cytochrome P450 inhibitors were used to trap the biosynthetic intermediates of highly oxygenated cuparene-type sesquiterpenes of F. velutipes. Of these, 1-aminobenzotriazole produced three less-highly oxygenated biosynthetic intermediates of enokipodins A-D; these were identified as (S)-(-)-cuparene-1,4-quinone and epimers at C-3 of 6-hydroxy-6-methyl-3-(1,2,2-trimethylcyclopentyl)- 2-cyclohexen-1-one. One of the epimers was found to be a new compound. |
| Rights: | http://creativecommons.org/licenses/by-nc/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/56115 |
| Appears in Collections: | 農学院・農学研究院 (Graduate School of Agriculture / Faculty of Agriculture) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 福士 幸治
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