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The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the nonclinical general adult population

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/56148

Title: The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the nonclinical general adult population
Authors: Nakai, Yukiei Browse this author
Inoue, Takeshi Browse this author →KAKEN DB
Toda, Hiroyuki Browse this author
Toyomaki, Atsuhito Browse this author →KAKEN DB
Nakato, Yasuya Browse this author
Nakagawa, Shin Browse this author →KAKEN DB
Kitaichi, Yuji Browse this author
Kameyama, Rie Browse this author
Hayashishita, Yoshiyuki Browse this author
Wakatsuki, Yumi Browse this author
Oba, Koji Browse this author →KAKEN DB
Tanabe, Hajime Browse this author
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Childhood abuse
Depression
Affective temperaments
TEMPS-A
Stressful life events
Structural equation model
Issue Date: Apr-2014
Publisher: Elsevier
Journal Title: Journal of Affective Disorders
Volume: 158
Start Page: 101
End Page: 107
Publisher DOI: 10.1016/j.jad.2014.02.004
PMID: 24655773
Abstract: Background: Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of major depression. We hypothesized that childhood abuse, affective temperaments, and adult stressful life events interact and influence depressive symptoms in the general adult population and tested this hypothesis in this study. Methods: The 294 participants from the nonclinical general adult population were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), Life Experiences Survey (LES), Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego auto-questionnaire (TEMPS-A), and Child Abuse and Trauma Scale (CATS). The data were analyzed with single and multiple regressions and structural equation modeling (Amos 20.0). Results: Childhood abuse indirectly predicted the severity of the depressive symptoms through affective temperaments measured by TEMPS-A in the structural equation modeling. Four temperaments depressive, cyclothymic, irritable, and anxious - directly predicted the severity of depressive symptoms and the negative appraisal of life events during the past year. The negative appraisal of life events during the past year mildly, but significantly, predicted the severity of depressive symptoms. Limitations: The subjects of this study were nonclinical. The findings might not be generalized to patients with mood disorders. Conclusions: This study suggests that childhood abuse, especially neglect, indirectly increased depressive symptoms through increased affective temperaments, which, in turn, increase the negative appraisal of stressful life events. An important role of affective temperaments in the effect of childhood abuse and stressful life events on depressive symptoms was suggested. (C) 2014 Elsevier B.V. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/56148
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 井上 猛

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