| Title: | Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood |
| Authors: | Okada, Emiko Browse this author →KAKEN DB |
| Sasaki, Seiko Browse this author →KAKEN DB |
| Kashino, Ikuko Browse this author |
| Matsuura, Hideyuki Browse this author →KAKEN DB |
| Miyashita, Chihiro Browse this author →KAKEN DB |
| Kobayashi, Sumitaka Browse this author →KAKEN DB |
| Itoh, Kumiko Browse this author |
| Ikeno, Tamiko Browse this author →KAKEN DB |
| Tamakoshi, Akiko Browse this author →KAKEN DB |
| Kishi, Reiko Browse this author →KAKEN DB |
| Keywords: | Perfluoroalkyl acids |
| Perfluorotridecanoic acid |
| Prenatal exposure |
| Allergic diseases |
| Eczema |
| Issue Date: | Apr-2014 |
| Publisher: | Elsevier |
| Journal Title: | Environment International |
| Volume: | 65 |
| Start Page: | 127 |
| End Page: | 134 |
| Publisher DOI: | 10.1016/j.envint.2014.01.007 |
| PMID: | 24486970 |
| Abstract: | Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that are detected in humans worldwide. Laboratory animal studies have shown that PFAAs are associated with immunotoxic effects. However, epidemiological studies investigating the role of PFAAs, in particular PFAAs with longer chains than perfluorooctanoic acid, are scarce. We investigated associations between prenatal exposure to PFAAs, including long-chain compounds, and infant allergic diseases at 12 and 24 months in a large study population. The participants included mothers and their infants who enrolled in the Hokkaido Study on Environment and Children's Health 2003-2009. Eleven PFAAs were measured in maternal plasma taken at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. Characteristics of participants and information on infant allergic diseases were obtained from self-administered questionnaires and medical records. At 24 months, the adjusted odds ratio (OR) (first vs. fourth quartiles) for eczema in association with higher maternal perfluorotridecanoic acid (PFTrDA) levels was 0.62 (95% confidence interval (CI) 0.45, 0.86). After stratification by gender, the adjusted ORs in female infants from mothers with higher maternal perfluoroundecanoic acid (PFUnDA) and PFTrDA levels were also statistically significant (PFUnDA: OR = 0.50; 95% CI, 030, 0.81; PFTrDA: OR = 0.39; 95% CI, 0.23, 0.64). Our findings suggest that lower prenatal exposure to PFTrDA may decrease the risk of developing eczema in early childhood, only in female infants. 2014 Elsevier Ltd. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56344 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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