HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood

Files in This Item:
Environ Int_65_127-134.pdf660.97 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/56344

Title: Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood
Authors: Okada, Emiko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Kashino, Ikuko Browse this author
Matsuura, Hideyuki Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Itoh, Kumiko Browse this author
Ikeno, Tamiko Browse this author →KAKEN DB
Tamakoshi, Akiko Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Perfluoroalkyl acids
Perfluorotridecanoic acid
Prenatal exposure
Allergic diseases
Eczema
Issue Date: Apr-2014
Publisher: Elsevier
Journal Title: Environment International
Volume: 65
Start Page: 127
End Page: 134
Publisher DOI: 10.1016/j.envint.2014.01.007
PMID: 24486970
Abstract: Perfluoroalkyl acids (PFAAs) are persistent organic pollutants that are detected in humans worldwide. Laboratory animal studies have shown that PFAAs are associated with immunotoxic effects. However, epidemiological studies investigating the role of PFAAs, in particular PFAAs with longer chains than perfluorooctanoic acid, are scarce. We investigated associations between prenatal exposure to PFAAs, including long-chain compounds, and infant allergic diseases at 12 and 24 months in a large study population. The participants included mothers and their infants who enrolled in the Hokkaido Study on Environment and Children's Health 2003-2009. Eleven PFAAs were measured in maternal plasma taken at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. Characteristics of participants and information on infant allergic diseases were obtained from self-administered questionnaires and medical records. At 24 months, the adjusted odds ratio (OR) (first vs. fourth quartiles) for eczema in association with higher maternal perfluorotridecanoic acid (PFTrDA) levels was 0.62 (95% confidence interval (CI) 0.45, 0.86). After stratification by gender, the adjusted ORs in female infants from mothers with higher maternal perfluoroundecanoic acid (PFUnDA) and PFTrDA levels were also statistically significant (PFUnDA: OR = 0.50; 95% CI, 030, 0.81; PFTrDA: OR = 0.39; 95% CI, 0.23, 0.64). Our findings suggest that lower prenatal exposure to PFTrDA may decrease the risk of developing eczema in early childhood, only in female infants. 2014 Elsevier Ltd. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/56344
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡田 恵美子

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University