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Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in Japan

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Title: Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in Japan
Authors: Abe, Takashige Browse this author →KAKEN DB
Kitamura, Hiroshi Browse this author
Obara, Wataru Browse this author
Matsumura, Nagahide Browse this author
Tsukamoto, Taiji Browse this author
Fujioka, Tomoaki Browse this author
Hara, Isao Browse this author
Murai, Sachiyo Browse this author
Shinohara, Nobuo Browse this author →KAKEN DB
Nonomura, Katsuya Browse this author →KAKEN DB
Keywords: urinary bladder
lymph nodes
neoplasm metastasis
Issue Date: Apr-2014
Publisher: Elsevier
Journal Title: Journal of Urology
Volume: 191
Issue: 4
Start Page: 932
End Page: 936
Publisher DOI: 10.1016/j.juro.2013.11.004
PMID: 24211599
Abstract: Purpose: We determined prognostic factors associated with prolonged survival after metastasectomy for urothelial carcinoma. Materials and Methods: A total of 42 patients who underwent resection of urothelial carcinoma metastases with curative intent at 4 Japanese university hospitals were included in analysis. Of the patients 41 of 42 underwent systemic chemotherapy before and/or after metastasectomy. Overall survival was analyzed using the Kaplan-Meier method. The relationship between clinical characteristics and survival was analyzed using the log rank test. Results: Metastasectomy included lymph node dissection in 20 cases, pulmonary resection in 12, pelvic exenteration in 3, resection of local recurrence in 2, resection of subcutaneous metastasis in 2, liver resection in 1 and other in 2. Median overall survival was 29 months (IQR 19-80) from the initiation of treatment for metastases and 26 months (IQR 11-90) from metastasectomy. The overall 5-year survival rate after metastasectomy was 31%. On univariate analysis patients treated with metastasectomy for a solitary lung or solitary lymph node metastasis had significantly longer survival than the others who underwent metastasectomy (81 vs 19 months, log rank test p = 0.0296). Conclusions: Long-term cancer control could be achieved in a subgroup of patients who undergo metastasectomy, especially those with a solitary lung or solitary lymph node metastasis.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 安部 崇重

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