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Hokkaido University Collection of Scholarly and Academic Papers >
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Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in Japan
| Title: | Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in Japan |
| Authors: | Abe, Takashige Browse this author →KAKEN DB | | Kitamura, Hiroshi Browse this author | | Obara, Wataru Browse this author | | Matsumura, Nagahide Browse this author | | Tsukamoto, Taiji Browse this author | | Fujioka, Tomoaki Browse this author | | Hara, Isao Browse this author | | Murai, Sachiyo Browse this author | | Shinohara, Nobuo Browse this author →KAKEN DB | | Nonomura, Katsuya Browse this author →KAKEN DB |
| Keywords: | urinary bladder | | urothelium | | carcinoma | | lymph nodes | | neoplasm metastasis |
| Issue Date: | Apr-2014 |
| Publisher: | Elsevier |
| Journal Title: | Journal of Urology |
| Volume: | 191 |
| Issue: | 4 |
| Start Page: | 932 |
| End Page: | 936 |
| Publisher DOI: | 10.1016/j.juro.2013.11.004 |
| PMID: | 24211599 |
| Abstract: | Purpose: We determined prognostic factors associated with prolonged survival after metastasectomy for urothelial carcinoma. Materials and Methods: A total of 42 patients who underwent resection of urothelial carcinoma metastases with curative intent at 4 Japanese university hospitals were included in analysis. Of the patients 41 of 42 underwent systemic chemotherapy before and/or after metastasectomy. Overall survival was analyzed using the Kaplan-Meier method. The relationship between clinical characteristics and survival was analyzed using the log rank test. Results: Metastasectomy included lymph node dissection in 20 cases, pulmonary resection in 12, pelvic exenteration in 3, resection of local recurrence in 2, resection of subcutaneous metastasis in 2, liver resection in 1 and other in 2. Median overall survival was 29 months (IQR 19-80) from the initiation of treatment for metastases and 26 months (IQR 11-90) from metastasectomy. The overall 5-year survival rate after metastasectomy was 31%. On univariate analysis patients treated with metastasectomy for a solitary lung or solitary lymph node metastasis had significantly longer survival than the others who underwent metastasectomy (81 vs 19 months, log rank test p = 0.0296). Conclusions: Long-term cancer control could be achieved in a subgroup of patients who undergo metastasectomy, especially those with a solitary lung or solitary lymph node metastasis. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56347 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 安部 崇重
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