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Interaction between Theileria orientalis 23-kDa piroplasm membrane protein and heparin

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.62.1-2.17

Title: Interaction between Theileria orientalis 23-kDa piroplasm membrane protein and heparin
Authors: Takemae, Hitoshi Browse this author
Sugi, Tatsuki Browse this author
Kobayashi, Kyousuke Browse this author
Murakoshi, Fumi Browse this author
Recuenco, Frances C Browse this author
Ishiwa, Akiko Browse this author
Inomata, Atsuko Browse this author
Horimoto, Taisuke Browse this author →KAKEN DB
Yokoyama, Naoaki Browse this author →KAKEN DB
Kato, Kentaro Browse this author
Keywords: Glycoarray
Heparin
23-kDa piroplasm membrane protein
Issue Date: May-2014
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 62
Issue: 1&2
Start Page: 17
End Page: 24
Abstract: The 23-kDa piroplasm membrane protein of Theileria orientalis (p23) is an immunogenic protein expressed during the intraerythrocytic stage of the parasite; its function, however, remains unclear. To evaluate the host factor or factors that interact with p23, we examined the binding of p23 to components of the host cell surface. Recombinant p23 protein of the Ikeda genotype failed to bind to bovine red blood cells or to peripheral blood mononuclear cells, but did bind to Madin-Darby Bovine Kidney (MDBK) cells. A glycoarray assay showed that recombinant p23 proteins from the three genotypes bound to heparin, indicating that p23 is a heparin-binding Theileria surface molecule. Further analysis of heparin-binding molecules is useful for understanding attachment and invasion of T. orientalis merozoites.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/56386
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
Japanese Journal of Veterinary Research > Volume 62 Number 1&2

Submitter: 獣医学部図書室

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