Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
MicroRNA expression profiling of cat and dog kidneys
Title: | MicroRNA expression profiling of cat and dog kidneys |
Authors: | Ichii, Osamu Browse this author →KAKEN DB | Otsuka, Saori Browse this author →KAKEN DB | Ohta, Hiroshi Browse this author →KAKEN DB | Yabuki, Akira Browse this author →KAKEN DB | Horino, Taro Browse this author | Kon, Yasuhiro Browse this author →KAKEN DB |
Keywords: | Companion animals | Cat | Dog | MicroRNA | Kidney | RNA sequencing |
Issue Date: | Apr-2014 |
Publisher: | Elsevier |
Journal Title: | Research in Veterinary Science |
Volume: | 96 |
Issue: | 2 |
Start Page: | 299 |
End Page: | 303 |
Publisher DOI: | 10.1016/j.rvsc.2014.01.003 |
PMID: | 24530019 |
Abstract: | MicroRNAs (miRNAs) play a role in the pathogenesis of certain diseases and may serve as biomarkers. Here, we present the first analysis of miRNA expression in the kidneys of healthy cats and dogs. Kidneys were divided into renal cortex (CO) and medulla (MD), and RNA sequence analysis was performed using the mouse genome as a reference. A total of 277, 276, 295, and 297 miRNAs were detected in cat CO, cat MD, dog CO, and dog MD, respectively. By comparing the expression ratio of CO to MD, we identified highly expressed miRNAs in each tissue as follows: 41 miRNAs including miR-192-5p in cat CO; 45 miRNAs including miR-323-3p in dog CO; 78 miRNAs including miR-20a-5p in cat MD; and 11 miRNAs including miR-132-5p in dog MD. Further, the target miRNAs of these miRNAs were identified. These data provide veterinary medicine critical information regarding renal miRNA expression. (C) 2014 Elsevier Ltd. All rights reserved. |
Relation: | http://www.sciencedirect.com/science/journal/00345288 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/56453 |
Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 市居 修
|