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MicroRNA expression profiling of cat and dog kidneys

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Title: MicroRNA expression profiling of cat and dog kidneys
Authors: Ichii, Osamu Browse this author →KAKEN DB
Otsuka, Saori Browse this author →KAKEN DB
Ohta, Hiroshi Browse this author →KAKEN DB
Yabuki, Akira Browse this author →KAKEN DB
Horino, Taro Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: Companion animals
RNA sequencing
Issue Date: Apr-2014
Publisher: Elsevier
Journal Title: Research in Veterinary Science
Volume: 96
Issue: 2
Start Page: 299
End Page: 303
Publisher DOI: 10.1016/j.rvsc.2014.01.003
PMID: 24530019
Abstract: MicroRNAs (miRNAs) play a role in the pathogenesis of certain diseases and may serve as biomarkers. Here, we present the first analysis of miRNA expression in the kidneys of healthy cats and dogs. Kidneys were divided into renal cortex (CO) and medulla (MD), and RNA sequence analysis was performed using the mouse genome as a reference. A total of 277, 276, 295, and 297 miRNAs were detected in cat CO, cat MD, dog CO, and dog MD, respectively. By comparing the expression ratio of CO to MD, we identified highly expressed miRNAs in each tissue as follows: 41 miRNAs including miR-192-5p in cat CO; 45 miRNAs including miR-323-3p in dog CO; 78 miRNAs including miR-20a-5p in cat MD; and 11 miRNAs including miR-132-5p in dog MD. Further, the target miRNAs of these miRNAs were identified. These data provide veterinary medicine critical information regarding renal miRNA expression. (C) 2014 Elsevier Ltd. All rights reserved.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市居 修

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