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Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/56519

Title: Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for squamous cell carcinoma of the nasal vestibule: a report of two cases
Authors: Homma, Akihiro Browse this author →KAKEN DB
Suzuki, Fumiyuki Browse this author
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Sakashita, Tomohiro Browse this author
Yoshida, Daisuke Browse this author
Tsuchiya, Kazuhiko Browse this author
Onimaru, Rikiya Browse this author →KAKEN DB
Oridate, Nobuhiko Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Head and neck cancer
Intra-arterial
Nasal vestibule
Squamous cell carcinoma
Chemoradiotherapy
Issue Date: Oct-2012
Publisher: Springer
Journal Title: International Cancer Conference Journal
Volume: 1
Issue: 4
Start Page: 215
End Page: 219
Publisher DOI: 10.1007/s13691-012-0044-z
Abstract: Squamous cell carcinoma of the nasal vestibule (SCC-NV) is rare among head and neck malignancies. It behaves differently from cancers arising in the nasal cavity and paranasal sinuses, and skin cancer of the external nose. Prognosis is more favorable than nasal cavity tumors and less favorable than skin cancers. We experienced two cases of SCC-NV who were treated with rapid superselective high-dose cisplatin infusion with concomitant radiotherapy (RADPLAT). A 56-year-old male and a 68-year-old female with SCC-NV, classified as T4aN0M0 according to UICC and T2 according to Wang classification, were given superselective intra-arterial infusions of cisplatin, with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity, together with conventional radiotherapy. In both cases, the internal maxillary artery and the facial artery were considered to be feeders of the tumor. No serious adverse events have been observed in either patient to date during follow-up of 7.3 and 5.3 years, respectively. Both patients are alive without disease and show excellent cosmetic results. RADPLAT is considered to be useful for the treatment of patients with SCC of the nasal vestibule.
Rights: The final publication is available at Springer via http://dx.doi.org/10.1007/s13691-012-0044-z
Type: article (author version)
URI: http://hdl.handle.net/2115/56519
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 本間 明宏

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