| Title: | High Level of Serum Soluble Interleukin-2 Receptor at Transplantation Predicts Poor Outcome of Allogeneic Stem Cell Transplantation for Adult T Cell Leukemia |
| Authors: | Shigematsu, Akio Browse this author |
| Kobayashi, Naoki Browse this author |
| Yasui, Hiroshi Browse this author |
| Shindo, Motohiro Browse this author |
| Kakinoki, Yasutaka Browse this author |
| Koda, Kyuhei Browse this author |
| Iyama, Satoshi Browse this author |
| Kuroda, Hiroyuki Browse this author |
| Tsutsumi, Yutaka Browse this author |
| Imamura, Masahiro Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Adult T cell leukemia |
| Allogeneic stem cell transplantation |
| Region-wide study |
| Soluble interleukin-2 receptor |
| Prognostic factor |
| Issue Date: | Jun-2014 |
| Publisher: | Elsevier |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 20 |
| Issue: | 6 |
| Start Page: | 801 |
| End Page: | 805 |
| Publisher DOI: | 10.1016/j.bbmt.2014.02.014 |
| PMID: | 24565990 |
| Abstract: | The prognosis for adult T cell leukemia/lymphoma (ATL) is very poor, and only allogeneic hematopoietic stem cell transplantation (allo-SCT) has been considered to be a curative treatment for ATL. In this study, we retrospectively analyzed data for patients who had received allo-SCT for ATL in Hokkaido, the northernmost island of Japan, to determine prognostic factors. Fifty-six patients with a median age of 57 years received allo-SCT. Twenty-eight (50.0%) patients had acute type and 22 (46.4%) had lymphoma type. Twenty-three (41.1%) patients received allo-SCT in complete remission (CR), whereas the others were in non-CR. Seventeen (30.4%) patients received myeloablative conditioning and the others received reduced-intensity conditioning. With a median follow-up period of 48 months (range, 17 to 134 months), 1-year overall survival (OS) and 5-year OS rates were 55.4% and 46.1%, respectively. The survival curve reached a plateau at 22 months after stem cell transplantation (SCT). Male sex, high level of serum soluble interleukin-2 receptor (sIL-2R) at SCT, and non-CR at SCT were determined to be significant risk factors for OS. A high level of sIL-2R at SCT was a risk factor for poor OS in patients with non-CR at SCT by univariate analysis (P = .02), and it remained significant after adjustment by sex (hazard ratio, 2.73 [95% confidence interval, 1.07 to 7.90]). A high level of sIL-2R at SCT was also determined to be a risk factor for disease progression (P = .02). This region-wide study showed encouraging results for survival after allo-SCT for ATL and demonstrated for the first time that a high level of sIL-2R at SCT predicts worse SCT outcome. (C) 2014 American Society for Blood and Marrow Transplantation. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56537 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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