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Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal

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Title: Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal
Authors: Paudel, Sarad Browse this author
Mikota, Susan K. Browse this author
Nakajima, Chie Browse this author →KAKEN DB
Gairhe, Kamal P. Browse this author
Maharjan, Bhagwan Browse this author
Thapa, Jeewan Browse this author
Poudel, Ajay Browse this author
Shimozuru, Michito Browse this author
Suzuki, Yasuhiko Browse this author →KAKEN DB
Tsubota, Toshio Browse this author →KAKEN DB
Keywords: Asian elephants
Mycobacterium tuberculosis
Multi-locus variable number tandem repeat analysis (MLVA)
Spoligotyping
Issue Date: May-2014
Publisher: Elsevier
Journal Title: Tuberculosis
Volume: 94
Issue: 3
Start Page: 287
End Page: 292
Publisher DOI: 10.1016/j.tube.2013.12.008
PMID: 24566285
Abstract: Mycobacterium tuberculosis was cultured from the lung tissues of 3 captive elephants in Nepal that died with extensive lung lesions. Spoligotyping, TbD1 detection and multi-locus variable number of tandem repeat analysis (MLVA) results suggested 3 isolates belonged to a specific lineage of Indo-Oceanic clade, EAI5 SIT 138. One of the elephant isolates had a new synonymous single nucleotide polymorphism (SNP) T231C in the gyrA sequence, and the same SNP was also found in human isolates in Nepal. MLVA results and transfer history of the elephants suggested that 2 of them might be infected with M. tuberculosis from the same source. These findings indicated the source of M. tuberculosis infection of those elephants were local residents, presumably their handlers. Further investigation including detailed genotyping of elephant and human isolates is needed to clarify the infection route and eventually prevent the transmission of tuberculosis to susceptible hosts. (C) 2014 Elsevier Ltd. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/56576
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坪田 敏男

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