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Mathematical modeling of calcium waves induced by mechanical stimulation in keratinocytes
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| Title: | Mathematical modeling of calcium waves induced by mechanical stimulation in keratinocytes |
| Authors: | Kobayashi, Yasuaki Browse this author | | Sanno, Yumi Browse this author | | Sakai, Akihiko Browse this author | | Sawabu, Yusuke Browse this author | | Tsutsumi, Moe Browse this author | | Goto, Makiko Browse this author | | Kitahata, Hiroyuki Browse this author →KAKEN DB | | Nakata, Satoshi Browse this author →KAKEN DB | | Kumamoto, Junichi Browse this author | | Denda, Mitsuhiro Browse this author | | Nagayama, Masaharu Browse this author →KAKEN DB |
| Issue Date: | 24-Mar-2014 |
| Publisher: | Public Library of Science (PLoS) |
| Journal Title: | PLoS One |
| Volume: | 9 |
| Issue: | 3 |
| Start Page: | e92650-1 |
| End Page: | e92650-10 |
| Publisher DOI: | 10.1371/journal.pone.0092650 |
| PMID: | 24663805 |
| Abstract: | Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on experimental observations of in vitro calcium waves in keratinocytes induced by mechanical stimulation, and present a mathematical model that can describe the experimentally observed wave behavior that includes finite-range wave propagation and a ring-shaped pattern. A mechanism of the ring formation hypothesized by our model may be related to similar calcium propagation patterns observed during the wound healing process in the epidermis. We discuss a possible extension of our model that may serve as a tool for investigating the mechanisms of various skin diseases. |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/56610 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 長山 雅晴
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