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Mathematical modeling of calcium waves induced by mechanical stimulation in keratinocytes

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Title: Mathematical modeling of calcium waves induced by mechanical stimulation in keratinocytes
Authors: Kobayashi, Yasuaki Browse this author
Sanno, Yumi Browse this author
Sakai, Akihiko Browse this author
Sawabu, Yusuke Browse this author
Tsutsumi, Moe Browse this author
Goto, Makiko Browse this author
Kitahata, Hiroyuki Browse this author →KAKEN DB
Nakata, Satoshi Browse this author →KAKEN DB
Kumamoto, Junichi Browse this author
Denda, Mitsuhiro Browse this author
Nagayama, Masaharu Browse this author →KAKEN DB
Issue Date: 24-Mar-2014
Publisher: Public Library of Science (PLoS)
Journal Title: PLoS One
Volume: 9
Issue: 3
Start Page: e92650-1
End Page: e92650-10
Publisher DOI: 10.1371/journal.pone.0092650
PMID: 24663805
Abstract: Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on experimental observations of in vitro calcium waves in keratinocytes induced by mechanical stimulation, and present a mathematical model that can describe the experimentally observed wave behavior that includes finite-range wave propagation and a ring-shaped pattern. A mechanism of the ring formation hypothesized by our model may be related to similar calcium propagation patterns observed during the wound healing process in the epidermis. We discuss a possible extension of our model that may serve as a tool for investigating the mechanisms of various skin diseases.
Type: article
Appears in Collections:電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長山 雅晴

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