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GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3
| Title: | GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3 |
| Authors: | Boku, Shuken Browse this author →KAKEN DB | | Nakagawa, Shin Browse this author →KAKEN DB | | Takamura, Naoki Browse this author | | Kato, Akiko Browse this author | | Takebayashi, Minoru Browse this author | | Hisaoka-Nakashima, Kazue Browse this author | | Omiya, Yuki Browse this author | | Inoue, Takeshi Browse this author →KAKEN DB | | Kusumi, Ichiro Browse this author →KAKEN DB |
| Keywords: | Neurogenesis | | Antidepressant | | Astrocyte | | GDNF | | STAT3 |
| Issue Date: | 17-May-2013 |
| Publisher: | Academic Press Inc Elsevier Science |
| Journal Title: | Biochemical And Biophysical Research Communications |
| Volume: | 434 |
| Issue: | 4 |
| Start Page: | 779 |
| End Page: | 784 |
| Publisher DOI: | 10.1016/j.bbrc.2013.04.011 |
| PMID: | 23603362 |
| Abstract: | While the pro-neurogenic actions of antidepressants in the adult hippocampal dentate gyrus (DG) are thought to be one of the mechanisms through which antidepressants exert their therapeutic actions, antidepressants do not increase proliferation of neural precursor cells derived from the adult DG. Because previous studies showed that antidepressants increase the expression and secretion of glial cell line-derived neurotrophic factor (GDNF) in C6 glioma cells derived from rat astrocytes and GDNF increases neurogenesis in adult DG in vivo, we investigated the effects of GDNF on the proliferation, differentiation and apoptosis of cultured neural precursor cells derived from the adult DG. Data showed that GDNF facilitated the differentiation of neural precursor cells into astrocytes but had no effect on their proliferation or apoptosis. Moreover, GDNF increased the phosphorylation of STAT3, and both a specific inhibitor of STAT3 and lentiviral shRNA for STAT3 decreased their differentiation into astrocytes. Taken together, our findings suggest that GDNF facilitates astrogliogenesis from neural precursor cells in adult DG through activating STAT3 and that this action might indirectly affect neurogenesis. (C) 2013 Elsevier Inc. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56637 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 朴 秀賢
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