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GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3

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Biochem Biophys Res Commun_434(4)_779-784.pdf1.72 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/56637

Title: GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3
Authors: Boku, Shuken Browse this author →KAKEN DB
Nakagawa, Shin Browse this author →KAKEN DB
Takamura, Naoki Browse this author
Kato, Akiko Browse this author
Takebayashi, Minoru Browse this author
Hisaoka-Nakashima, Kazue Browse this author
Omiya, Yuki Browse this author
Inoue, Takeshi Browse this author →KAKEN DB
Kusumi, Ichiro Browse this author →KAKEN DB
Keywords: Neurogenesis
Antidepressant
Astrocyte
GDNF
STAT3
Issue Date: 17-May-2013
Publisher: Academic Press Inc Elsevier Science
Journal Title: Biochemical And Biophysical Research Communications
Volume: 434
Issue: 4
Start Page: 779
End Page: 784
Publisher DOI: 10.1016/j.bbrc.2013.04.011
PMID: 23603362
Abstract: While the pro-neurogenic actions of antidepressants in the adult hippocampal dentate gyrus (DG) are thought to be one of the mechanisms through which antidepressants exert their therapeutic actions, antidepressants do not increase proliferation of neural precursor cells derived from the adult DG. Because previous studies showed that antidepressants increase the expression and secretion of glial cell line-derived neurotrophic factor (GDNF) in C6 glioma cells derived from rat astrocytes and GDNF increases neurogenesis in adult DG in vivo, we investigated the effects of GDNF on the proliferation, differentiation and apoptosis of cultured neural precursor cells derived from the adult DG. Data showed that GDNF facilitated the differentiation of neural precursor cells into astrocytes but had no effect on their proliferation or apoptosis. Moreover, GDNF increased the phosphorylation of STAT3, and both a specific inhibitor of STAT3 and lentiviral shRNA for STAT3 decreased their differentiation into astrocytes. Taken together, our findings suggest that GDNF facilitates astrogliogenesis from neural precursor cells in adult DG through activating STAT3 and that this action might indirectly affect neurogenesis. (C) 2013 Elsevier Inc. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/56637
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 朴 秀賢

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