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3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease

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Title: 3D neuromelanin-sensitive magnetic resonance imaging with semi-automated volume measurement of the substantia nigra pars compacta for diagnosis of Parkinson's disease
Authors: Ogisu, Kimihiro Browse this author
Kudo, Kohsuke Browse this author →KAKEN DB
Sasaki, Makoto Browse this author →KAKEN DB
Sakushima, Ken Browse this author
Yabe, Ichiro Browse this author →KAKEN DB
Sasaki, Hidenao Browse this author →KAKEN DB
Terae, Satoshi Browse this author →KAKEN DB
Nakanishi, Mitsuhiro Browse this author
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Neuromelanin
MRI
Parkinson's disease
Substantia nigra
Issue Date: Jun-2013
Publisher: Springer
Journal Title: Neuroradiology
Volume: 55
Issue: 6
Start Page: 719
End Page: 724
Publisher DOI: 10.1007/s00234-013-1171-8
PMID: 23525598
Abstract: Neuromelanin-sensitive MRI has been reported to be used in the diagnosis of Parkinson's disease (PD), which results from loss of dopamine-producing cells in the substantia nigra pars compacta (SNc). In this study, we aimed to apply a 3D turbo field echo (TFE) sequence for neuromelanin-sensitive MRI and to evaluate the diagnostic performance of semi-automated method for measurement of SNc volume in patients with PD. We examined 18 PD patients and 27 healthy volunteers (control subjects). A 3D TFE technique with off-resonance magnetization transfer pulse was used for neuromelanin-sensitive MRI on a 3T scanner. The SNc volume was semi-automatically measured using a region-growing technique at various thresholds (ranging from 1.66 to 2.48), with the signals measured relative to that for the superior cerebellar peduncle. Receiver operating characteristic (ROC) analysis was performed at all thresholds. Intra-rater reproducibility was evaluated by intraclass correlation coefficient (ICC). The average SNc volume in the PD group was significantly smaller than that in the control group at all the thresholds (P < 0.01, student t test). At higher thresholds (> 2.0), the area under the curve of ROC (Az) increased (0.88). In addition, we observed balanced sensitivity and specificity (0.83 and 0.85, respectively). At lower thresholds, sensitivity tended to increase but specificity reduced in comparison with that at higher thresholds. ICC was larger than 0.9 when the threshold was over 1.86. Our method can distinguish the PD group from the control group with high sensitivity and specificity, especially for early stage of PD.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/56640
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 白土 博樹

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