|
|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine
| Title: | Immunohistochemical molecular expression profile of metastatic brain tumor for potent personalized medicine |
| Authors: | Kato, Yasutaka Browse this author | | Nishihara, Hiroshi Browse this author →KAKEN DB | | Yuzawa, Sayaka Browse this author | | Mohri, Hiromi Browse this author | | Kanno, Hiromi Browse this author | | Hatanaka, Yutaka Browse this author →KAKEN DB | | Kimura, Taichi Browse this author →KAKEN DB | | Tanino, Mishie Browse this author →KAKEN DB | | Tanaka, Shinya Browse this author →KAKEN DB |
| Keywords: | Metastatic brain tumor | | Immunohistochemistry | | Molecular expression profile | | Personalized medicine |
| Issue Date: | Jul-2013 |
| Publisher: | Springer Japan |
| Journal Title: | Brain Tumor Pathology |
| Volume: | 30 |
| Issue: | 3 |
| Start Page: | 167 |
| End Page: | 174 |
| Publisher DOI: | 10.1007/s10014-012-0124-y |
| PMID: | 23180004 |
| Abstract: | Recent progress in molecule-targeting therapy may yield personalized therapeutic strategies for patients with metastatic brain tumors (MBT), the most frequently encountered intracranial tumors. For this purpose, we investigated the molecular expression profile of MBT to establish the pathological basis for personalized diagnosis. We studied 166 MBT specimens including 70 cases of lung cancer and 34 cases of breast cancer, and performed immunostaining for EGFR, COX-2, and O-6-methylguanine-DNA methyltransferase (MGMT), among others, which could be target molecules for therapeutic agents or enable prediction of drug efficacy. Loss of MGMT expression was observed in approximately 20–40 % of MBT derived from lung, breast, and gastrointestinal cancers, indicating the possibility of treatment of MBT patients with temozolomide. In addition, MBT expressed a variety of receptor tyrosine kinases, for example EGFR and HER2, and signal transduction molecules, for example phospho-mTOR and COX-2, irrespective of tumor origin, enabling individualized medication with molecule-targeting drugs. We also identified alteration of molecular expression profile in 4 MBT cases during recurrence. Our results not only reveal the molecular characteristics of MBT but also suggest the possibility of potent personalized medicine for MBT patients. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56648 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 西原 広史
|
