HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning

Files in This Item:
Bone Marrow Transplant.pdf868.5 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/56649

Title: Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning
Authors: Koyama, Motoko Browse this author
Hashimoto, Daigo Browse this author
Nagafuji, Koji Browse this author
Eto, Tetsuya Browse this author
Ohno, Yuju Browse this author
Aoyama, Kazutoshi Browse this author
Iwasaki, Hiromi Browse this author
Miyamoto, Toshihiro Browse this author
Hill, Geoffrey R. Browse this author
Akashi, Koichi Browse this author
Teshima, Takanori Browse this author →KAKEN DB
Keywords: graft rejection
bone marrow transplantation
cord blood transplantation
Issue Date: Jan-2014
Publisher: Nature Publishing Group
Journal Title: Bone Marrow Transplantation
Volume: 49
Issue: 1
Start Page: 110
End Page: 115
Publisher DOI: 10.1038/bmt.2013.134
PMID: 24013691
Abstract: Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT.
Type: article (author version)
URI: http://hdl.handle.net/2115/56649
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 豊嶋 崇徳

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

 - Hokkaido University