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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
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Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning
| Title: | Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning |
| Authors: | Koyama, Motoko Browse this author | | Hashimoto, Daigo Browse this author | | Nagafuji, Koji Browse this author | | Eto, Tetsuya Browse this author | | Ohno, Yuju Browse this author | | Aoyama, Kazutoshi Browse this author | | Iwasaki, Hiromi Browse this author | | Miyamoto, Toshihiro Browse this author | | Hill, Geoffrey R. Browse this author | | Akashi, Koichi Browse this author | | Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | graft rejection | | bone marrow transplantation | | cord blood transplantation |
| Issue Date: | Jan-2014 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 49 |
| Issue: | 1 |
| Start Page: | 110 |
| End Page: | 115 |
| Publisher DOI: | 10.1038/bmt.2013.134 |
| PMID: | 24013691 |
| Abstract: | Graft rejection remains a major obstacle in allogeneic hematopoietic SCT following reduced-intensity conditioning (RIC-SCT), particularly after cord blood transplantation (CBT). In a murine MHC-mismatched model of RIC-SCT, primary graft rejection was associated with activation and expansion of donor-reactive host T cells in peripheral blood and BM early after SCT. Donor-derived dendritic cells are at least partly involved in host T-cell activation. We then evaluated if such an expansion of host T cells could be associated with graft rejection after RIC-CBT. Expansion of residual host lymphocytes was observed in 4/7 patients with graft rejection at 3 weeks after CBT, but in none of the 17 patients who achieved engraftment. These results suggest the crucial role of residual host T cells after RIC-SCT in graft rejection and expansion of host T cells could be a marker of graft rejection. Development of more efficient T cell-suppressive conditioning regimens may be necessary in the context of RIC-SCT. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56649 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 豊嶋 崇徳
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