| Title: | Human intestinal spirochetosis is significantly associated with sessile serrated adenomas/polyps |
| Authors: | Omori, Saori Browse this author |
| Mabe, Katsuhiro Browse this author |
| Hatanaka, Kanako Browse this author |
| Ono, Masayoshi Browse this author |
| Matsumoto, Mio Browse this author |
| Takahashi, Masakazu Browse this author |
| Yoshida, Takeshi Browse this author |
| Ono, Shoko Browse this author |
| Shimizu, Yuichi Browse this author →KAKEN DB |
| Sugai, Nozomi Browse this author |
| Suzuki, Akira Browse this author |
| Katsuki, Shinichi Browse this author |
| Fujii, Takahiro Browse this author |
| Kato, Mototsugu Browse this author →KAKEN DB |
| Asaka, Masahiro Browse this author →KAKEN DB |
| Sakamoto, Naoya Browse this author →KAKEN DB |
| Keywords: | Human intestinal spirochetosis |
| Sessile serrated adenoma/polyps |
| Serrated lesion |
| Issue Date: | Jul-2014 |
| Publisher: | Elsevier |
| Journal Title: | Pathology, Research and Practice |
| Volume: | 210 |
| Issue: | 7 |
| Start Page: | 440 |
| End Page: | 443 |
| Publisher DOI: | 10.1016/j.prp.2014.03.007 |
| PMID: | 24767254 |
| Abstract: | It remains unclear whether or not human intestinal spirochetosis (HIS) has any associated symptoms or lesions. In this study, we assessed the prevalence of HIS in sessile serrated adenomas/polyps (SSA/Ps) and their possible association. Following identification of early cecal cancer with SSA/P accompanied by a colonization of HIS, we went on to conduct a retrospective case-control study using endoscopically resected SSA/P specimens to examine the frequency of HIS infection in SSA/Ps. Nineteen SSA/P cases and 172 controls were obtained. The rate of HIS infection was significantly higher at 52.6% (10/19) in the SSA/P cases compared to the controls at 8.1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps. (C) 2014 Elsevier GmbH. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/56700 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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