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Human intestinal spirochetosis is significantly associated with sessile serrated adenomas/polyps

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Title: Human intestinal spirochetosis is significantly associated with sessile serrated adenomas/polyps
Authors: Omori, Saori Browse this author
Mabe, Katsuhiro Browse this author
Hatanaka, Kanako Browse this author
Ono, Masayoshi Browse this author
Matsumoto, Mio Browse this author
Takahashi, Masakazu Browse this author
Yoshida, Takeshi Browse this author
Ono, Shoko Browse this author
Shimizu, Yuichi Browse this author →KAKEN DB
Sugai, Nozomi Browse this author
Suzuki, Akira Browse this author
Katsuki, Shinichi Browse this author
Fujii, Takahiro Browse this author
Kato, Mototsugu Browse this author →KAKEN DB
Asaka, Masahiro Browse this author →KAKEN DB
Sakamoto, Naoya Browse this author →KAKEN DB
Keywords: Human intestinal spirochetosis
Sessile serrated adenoma/polyps
Serrated lesion
Issue Date: Jul-2014
Publisher: Elsevier
Journal Title: Pathology, Research and Practice
Volume: 210
Issue: 7
Start Page: 440
End Page: 443
Publisher DOI: 10.1016/j.prp.2014.03.007
PMID: 24767254
Abstract: It remains unclear whether or not human intestinal spirochetosis (HIS) has any associated symptoms or lesions. In this study, we assessed the prevalence of HIS in sessile serrated adenomas/polyps (SSA/Ps) and their possible association. Following identification of early cecal cancer with SSA/P accompanied by a colonization of HIS, we went on to conduct a retrospective case-control study using endoscopically resected SSA/P specimens to examine the frequency of HIS infection in SSA/Ps. Nineteen SSA/P cases and 172 controls were obtained. The rate of HIS infection was significantly higher at 52.6% (10/19) in the SSA/P cases compared to the controls at 8.1% (14/172). Our SSA/P series were associated with a remarkably higher rate of HIS than controls or than previously reported. This is the first report to provide evidence for potential association between HIS and SSA/Ps. (C) 2014 Elsevier GmbH. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 間部 克裕

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