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TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer

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Title: TRIM29 as a novel prostate basal cell marker for diagnosis of prostate cancer
Authors: Kanno, Yukiko Browse this author
Watanabe, Masashi Browse this author
Kimura, Taichi Browse this author →KAKEN DB
Nonomura, Katsuya Browse this author →KAKEN DB
Tanaka, Shinya Browse this author →KAKEN DB
Hatakeyama, Shigetsugu Browse this author →KAKEN DB
Keywords: TRIM29
Prostate cancer
Basal cell
Issue Date: Jun-2014
Publisher: Elsevier
Journal Title: Acta Histochemica
Volume: 116
Issue: 5
Start Page: 708
End Page: 712
Publisher DOI: 10.1016/j.acthis.2013.12.009
PMID: 24485335
Abstract: Tripartite motif protein 29 (TRIM29) is one of the TRIM family proteins, some of which function as E3 ubiquitin ligases. In this study, we investigated the usefulness of TRIM29 for diagnosis of prostate cancer Prostate tissues including carcinoma and non-carcinoma tissues obtained by needle biopsy and radical prostatectomy were used. Immunohistochemistry was performed according to standard procedures using an antibody against TRIM29. Immunohistochemical staining with an antibody against 34 beta E12, which recognizes cytokeratins 1, 5, 10 and 14, was performed as a control. Basal cells of normal prostatic glands were stained with anti-TRIM29 antibody in all cases, whereas prostate cancer tissues had no or little staining with anti-TRIM29 antibody. TRIM29 is selectively expressed in basal cells of the normal prostate gland, and immunohistochemical staining with anti-TRIM29 antibody showed the same expression pattern as that with 34 beta E12 in prostate cancer and its benign mimics. Our data indicate that TRIM29 may be useful for distinguishing prostate cancers from benign tissues. (C) 2013 Elsevier GmbH. All rights reserved.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 畠山 鎮次

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