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Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet
| Title: | Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet |
| Authors: | Matsui, Yuki Browse this author | | Tomaru, Utano Browse this author →KAKEN DB | | Miyoshi, Arina Browse this author | | Ito, Tomoki Browse this author | | Fukaya, Shinji Browse this author | | Miyoshi, Hideaki Browse this author →KAKEN DB | | Atsumi, Tatsuya Browse this author →KAKEN DB | | Ishizu, Akihiro Browse this author →KAKEN DB |
| Keywords: | Adipose tissue inflammation | | High fat diet | | Obesity | | TACE | | TNF-α |
| Issue Date: | Dec-2014 |
| Publisher: | Elsevier |
| Journal Title: | Experimental and Molecular Pathology |
| Volume: | 97 |
| Issue: | 3 |
| Start Page: | 354 |
| End Page: | 358 |
| Publisher DOI: | 10.1016/j.yexmp.2014.09.017 |
| PMID: | 25236578 |
| Abstract: | Obesity is a state in which chronic low-grade inflammation persists in adipose tissues. Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related diseases. Since TNF-α converting enzyme (TACE) is the major factor that induces soluble TNF-α, TACE has been noted as a pivotal regulator in this field. To reveal the role of TACE in adipose tissue inflammation, TACE-transgenic (TACE-Tg) and wild type (WT) mice were fed with high fat diet (HFD) or control diet for 16 weeks. At 13 weeks after the beginning of the diet, serum TNF-α and macrophage-related cytokine/chemokine levels were elevated in TACE-Tg mice fed with HFD (Tg-HFD mice), and the number of the so-called crown-like adipocyte was significantly increased in adipose tissues of Tg-HFD mice at the end of the experiment. Although macrophage infiltration was not detected in the adipose tissues at this time, fibrosis was observed around the crown-like adipocytes. These findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under HFD regimen. The collective evidence suggested that TACE could be a therapeutic target of HFD-induced obesity-related adipose tissue inflammation. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57002 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石津 明洋
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