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Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet

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Title: Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet
Authors: Matsui, Yuki Browse this author
Tomaru, Utano Browse this author →KAKEN DB
Miyoshi, Arina Browse this author
Ito, Tomoki Browse this author
Fukaya, Shinji Browse this author
Miyoshi, Hideaki Browse this author →KAKEN DB
Atsumi, Tatsuya Browse this author →KAKEN DB
Ishizu, Akihiro Browse this author →KAKEN DB
Keywords: Adipose tissue inflammation
High fat diet
Obesity
TACE
TNF-α
Issue Date: Dec-2014
Publisher: Elsevier
Journal Title: Experimental and Molecular Pathology
Volume: 97
Issue: 3
Start Page: 354
End Page: 358
Publisher DOI: 10.1016/j.yexmp.2014.09.017
PMID: 25236578
Abstract: Obesity is a state in which chronic low-grade inflammation persists in adipose tissues. Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related diseases. Since TNF-α converting enzyme (TACE) is the major factor that induces soluble TNF-α, TACE has been noted as a pivotal regulator in this field. To reveal the role of TACE in adipose tissue inflammation, TACE-transgenic (TACE-Tg) and wild type (WT) mice were fed with high fat diet (HFD) or control diet for 16 weeks. At 13 weeks after the beginning of the diet, serum TNF-α and macrophage-related cytokine/chemokine levels were elevated in TACE-Tg mice fed with HFD (Tg-HFD mice), and the number of the so-called crown-like adipocyte was significantly increased in adipose tissues of Tg-HFD mice at the end of the experiment. Although macrophage infiltration was not detected in the adipose tissues at this time, fibrosis was observed around the crown-like adipocytes. These findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under HFD regimen. The collective evidence suggested that TACE could be a therapeutic target of HFD-induced obesity-related adipose tissue inflammation.
Type: article (author version)
URI: http://hdl.handle.net/2115/57002
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石津 明洋

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