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Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects

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Title: Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects
Authors: Okada, Kazunori Browse this author
Mikami, Taisei Browse this author →KAKEN DB
Kaga, Sanae Browse this author
Nakabachi, Masahiro Browse this author
Abe, Ayumu Browse this author
Yokoyama, Shinobu Browse this author
Nishino, Hisao Browse this author
Nishida, Mutsumi Browse this author →KAKEN DB
Shimizu, Chikara Browse this author →KAKEN DB
Iwano, Hiroyuki Browse this author
Yamada, Satoshi Browse this author →KAKEN DB
Tsutsui, Hiroyuki Browse this author →KAKEN DB
Keywords: aging
left ventricle
diastolic function
myocardial relaxation
interventricular septum
Issue Date: Jul-2014
Publisher: Wiley
Journal Title: Journal of Clinical Ultrasound
Volume: 42
Issue: 6
Start Page: 341
End Page: 347
Publisher DOI: 10.1002/jcu.22126
PMID: 24436178
Abstract: Background: Left ventricular (LV) diastolic dysfunction is often observed in healthy older subjects without structural heart disease, although its exact mechanisms have not been established. A decrease in the aorto-septal angle (ASA), an alteration of LV shape due to aortic elongation, is also frequently seen in elderly subjects. The objective of this study was to evaluate whether it can contribute to LV diastolic dysfunction in healthy subjects. Methods: Echocardiography was performed in 77 healthy subjects (42 men, mean age 43.2 ± 13.8 years) to measure the ASA, early diastolic transmitral flow velocity (E), isovolumic relaxation time (IRT), and early diastolic mitral annular velocity (e′). The LV peak early diastolic longitudinal strain rate (GSRE) was measured using a two-dimensional speckle tracking imaging technique. Results: ASA was significantly correlated with E (r = 0.54, p < 0.001), IRT (r = −0.41, p < 0.001), e′ (r = 0.57, p < 0.001), and GSRE (r = 0.63, p < 0.001) and shown by stepwise multivariate analysis to be the strongest independent determinant of E, IRT, and GSRE, and one of the independent determinants of e′.Conclusions: The alteration of LV shape associated with reduced ASA may be one of the causes of LV diastolic dysfunction independently of age in otherwise healthy subjects.
Rights: This is the pre-peer-reviewed version of the following article: Journal of clinical ultrasound, 42(6), 2014, pp.341-347, which has been published in final form at
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岡田 一範

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