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Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects
Title: | Decreased aorto-septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects |
Authors: | Okada, Kazunori Browse this author | Mikami, Taisei Browse this author →KAKEN DB | Kaga, Sanae Browse this author | Nakabachi, Masahiro Browse this author | Abe, Ayumu Browse this author | Yokoyama, Shinobu Browse this author | Nishino, Hisao Browse this author | Nishida, Mutsumi Browse this author →KAKEN DB | Shimizu, Chikara Browse this author →KAKEN DB | Iwano, Hiroyuki Browse this author | Yamada, Satoshi Browse this author →KAKEN DB | Tsutsui, Hiroyuki Browse this author →KAKEN DB |
Keywords: | aging | left ventricle | diastolic function | myocardial relaxation | interventricular septum |
Issue Date: | Jul-2014 |
Publisher: | Wiley |
Journal Title: | Journal of Clinical Ultrasound |
Volume: | 42 |
Issue: | 6 |
Start Page: | 341 |
End Page: | 347 |
Publisher DOI: | 10.1002/jcu.22126 |
PMID: | 24436178 |
Abstract: | Background: Left ventricular (LV) diastolic dysfunction is often observed in healthy older subjects without structural heart disease, although its exact mechanisms have not been established. A decrease in the aorto-septal angle (ASA), an alteration of LV shape due to aortic elongation, is also frequently seen in elderly subjects. The objective of this study was to evaluate whether it can contribute to LV diastolic dysfunction in healthy subjects. Methods: Echocardiography was performed in 77 healthy subjects (42 men, mean age 43.2 ± 13.8 years) to measure the ASA, early diastolic transmitral flow velocity (E), isovolumic relaxation time (IRT), and early diastolic mitral annular velocity (e′). The LV peak early diastolic longitudinal strain rate (GSRE) was measured using a two-dimensional speckle tracking imaging technique. Results: ASA was significantly correlated with E (r = 0.54, p < 0.001), IRT (r = −0.41, p < 0.001), e′ (r = 0.57, p < 0.001), and GSRE (r = 0.63, p < 0.001) and shown by stepwise multivariate analysis to be the strongest independent determinant of E, IRT, and GSRE, and one of the independent determinants of e′.Conclusions: The alteration of LV shape associated with reduced ASA may be one of the causes of LV diastolic dysfunction independently of age in otherwise healthy subjects. |
Rights: | This is the pre-peer-reviewed version of the following article: Journal of clinical ultrasound, 42(6), 2014, pp.341-347, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jcu.22126/abstract. |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/57040 |
Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 岡田 一範
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