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Hokkaido University Collection of Scholarly and Academic Papers >
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Peer-reviewed Journal Articles, etc >
MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques
| Title: | MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques |
| Authors: | Ikeshita, Shunji Browse this author | | Miyatake, Yukiko Browse this author →KAKEN DB | | Otsuka, Noriyuki Browse this author | | Kasahara, Masanori Browse this author →KAKEN DB |
| Keywords: | Atherosclerosis | | NKG2D | | MICA/B | | Monocyte-derived macrophage |
| Issue Date: | Aug-2014 |
| Publisher: | Elsevier |
| Journal Title: | Experimental and Molecular Pathology |
| Volume: | 97 |
| Issue: | 1 |
| Start Page: | 171 |
| End Page: | 175 |
| Publisher DOI: | 10.1016/j.yexmp.2014.07.002 |
| PMID: | 24997223 |
| Abstract: | Infiltrating macrophages accumulate in fatty streak lesions and transform into foam cells, leading to the formation of atherosclerotic plaques. Inflammatory mechanisms underlying the plaque formation mediated by NKG2D-positive lymphocytes such as CD8(+) T cells, natural killer cells and natural killer T cells have been extensively investigated. Yet, the involvement of the NKG2D system itself remains poorly understood. Recent work in mouse models has shown that blockade of an NKG2D receptor ligand interaction reduces plaque formation and suppresses inflammation in aortae. In this study, we conducted immunohistochemical analysis of NKG2D ligand expression in autopsy-derived aortic specimens. Foam cells expressing NKG2D ligands MICA/B were found in advanced atherosclerotic lesions accompanied by a large necrotic core or hemorrhage. Human monocyte-derived macrophages treated in vitro with acetylated low-density lipoproteins enhanced expression of MICA/B and scavenger receptor A, thus accounting for NKG2D ligand expression in foam cells infiltrating atherosclerotic plaques. Our results suggest that, as in mice, the NKG2D system might be involved in the development of atherosclerosis in humans. (C) 2014 Elsevier Inc. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57053 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮武 由甲子
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