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Data Mining in Amino Acid Sequences of H3N2 Influenza Viruses Isolated during 1968 to 2006

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Title: Data Mining in Amino Acid Sequences of H3N2 Influenza Viruses Isolated during 1968 to 2006
Authors: Ito, Kimihito Browse this author →KAKEN DB
Igarashi, Manabu Browse this author →KAKEN DB
Takada, Ayato Browse this author →KAKEN DB
Issue Date: Jul-2006
Publisher: TU Ilmenau
Journal Title: Knowledge Media Technologies, First International Core-to-Core Workshop
Volume: 21
Start Page: 154
End Page: 158
Abstract: The hemagglutinin (HA) of influenza viruses undergoes antigenic drift to escape from antibody-mediated immune pressure. In order to predict possible structural changes of the HA molecules in future, it is important to understand the patterns of amino acid mutations and structural changes in the past. We performed a retrospective and comprehensive analysis of structural changes in H3 hemagglutinins of human influenza viruses isolated during 1968 to 2006. Amino acid sequence data of more than 2000 strains have been collected from NCBI Influenza virus resources. Information theoretic analysis of the collected sequences revealed a number of simultaneous mutations of amino acids at two or more different positions (correlated mutations). We also calculated the net charge of the HA1 subunit, based on the number of charged amino acid residues, and found that the net charge increased linearly from 1968 to 1984 and, after then, has been saturated. This level of the net charge may be an upper limit for H3 HA to be functional. It is noted that ”correlated mutations” with the conversion of acidic and basic amino acid residues between two different positions were frequently found after 1984, suggesting that these mutations contributed to counterbalancing effect to keep the net charge of the HA . These approaches may open the way to find the direction of future antigenic drift of influenza viruses.
Type: article
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊藤 公人

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