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Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas

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Title: Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas
Authors: Sakashita, Tomohiro Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Suzuki, Seigo Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author
Oridate, Nobuhiko Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Immunohistochemistry
local recurrence
head and neck cancer
Issue Date: Sep-2013
Publisher: Informa
Journal Title: Acta oto-laryngologica
Volume: 133
Issue: 9
Start Page: 984
End Page: 991
Publisher DOI: 10.3109/00016489.2013.795287
PMID: 23692432
Abstract: Conclusion: It was proved that cyclin D1-positive status in surgical margins was an independent prognostic indicator of local recurrence. The expression of cyclin D1 in tumor-free surgical margins may better predict local recurrence in patients with head and neck squamous cell carcinoma (HNSCC) after surgical treatment with curative intent. Objective: This retrospective study aimed to determine the prognostic indicators for local recurrence in HNSCC. Methods: A total of 116 HNSCC patients who underwent surgical treatment with curative intent and had histopathologically tumor-free margins were eligible for this study. The expression of p53 and cyclin D1 was assessed by immunohistochemical staining in surgical margins as well as in tumor specimens. Results: In all, 63 patients (54.3%) had p53-positive tumor specimens and 34 patients (29.3%) had p53-positive margins. Seventy-six patients (65.6%) had cyclin D1-positive tumor specimens and 54 patients (46.6%) had cyclin D1-positive margins. A significant difference in local control rates was observed between patients with cyclin D1-positive and -negative margins (77.2% vs 91.5%, log rank test, p = 0.0139). Multivariate Cox proportional hazards testing indicated that the hazard ratio of cyclin D1-positive margins for local recurrence was 4.58 (95% confidence interval 1.14–21.69, p = 0.0304).
Rights: Copyright (c) Informa
Type: article (author version)
URI: http://hdl.handle.net/2115/57076
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂下 智博

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