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Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer
| Title: | Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer |
| Authors: | Sakashita, Tomohiro Browse this author →KAKEN DB | | Homma, Akihiro Browse this author →KAKEN DB | | Oridate, Nobuhiko Browse this author →KAKEN DB | | Suzuki, Seigo Browse this author →KAKEN DB | | Hatakeyama, Hiromitsu Browse this author →KAKEN DB | | Kano, Satoshi Browse this author →KAKEN DB | | Mizumachi, Takatsugu Browse this author | | Yoshida, Daisuke Browse this author | | Fujima, Noriyuki Browse this author →KAKEN DB | | Fukuda, Satoshi Browse this author →KAKEN DB |
| Keywords: | Nodal metastasis | | preoperative chemotherapy | | RADPLAT |
| Issue Date: | Oct-2012 |
| Publisher: | Informa |
| Journal Title: | Acta oto-laryngologica |
| Volume: | 132 |
| Issue: | 10 |
| Start Page: | 1121 |
| End Page: | 1125 |
| Publisher DOI: | 10.3109/00016489.2012.680494 |
| PMID: | 22667997 |
| Abstract: | Conclusion: We conclude that intra-arterially injected cisplatin passed via lymph flow into sentinel nodes (SNs) as the platinum concentration in the SNs was higher than that in the non-sentinel nodes (NSNs). It is possible that preoperative intra-arterial chemotherapy targeting primary cancer also has a therapeutic effect on subclinical metastatic SNs. Objectives: Intra-arterial chemoradiotherapy has been reported to be effective against not only primary tumors but also nodal metastases. We considered the hypothesis that intra-arterially injected cisplatin passed via lymph flow into regional nodes. This study aimed to investigate intra-arterially injected cisplatin distribution to regional nodes by comparing platinum concentrations in SNs and NSNs. Methods: Five patients with T1-2 N0 tongue cancer were treated with preoperative intra-arterial chemotherapy (cisplatin, 100 mg/m2) targeting primary cancer. Partial glossectomy together with SN biopsy and elective neck dissection were performed 2 weeks after intra-arterial chemotherapy. Platinum concentrations in the lymph nodes were measured using a Zeeman atomic absorption spectrometer. Results: Thirteen SNs were harvested together with eight NSNs from the areas adjacent to the SNs. Platinum concentrations were then measured, revealing a significant difference in platinum concentration between the SNs and the NSNs (mean ± SD, 0.682 ± 0.246 µg/g vs 0.506 ± 0.274 µg/g; p = 0.049). |
| Rights: | Copyright (c) Informa |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57077 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 坂下 智博
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