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Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/57077

Title: Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer
Authors: Sakashita, Tomohiro Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Oridate, Nobuhiko Browse this author →KAKEN DB
Suzuki, Seigo Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author
Yoshida, Daisuke Browse this author
Fujima, Noriyuki Browse this author →KAKEN DB
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Nodal metastasis
preoperative chemotherapy
RADPLAT
Issue Date: Oct-2012
Publisher: Informa
Journal Title: Acta oto-laryngologica
Volume: 132
Issue: 10
Start Page: 1121
End Page: 1125
Publisher DOI: 10.3109/00016489.2012.680494
PMID: 22667997
Abstract: Conclusion: We conclude that intra-arterially injected cisplatin passed via lymph flow into sentinel nodes (SNs) as the platinum concentration in the SNs was higher than that in the non-sentinel nodes (NSNs). It is possible that preoperative intra-arterial chemotherapy targeting primary cancer also has a therapeutic effect on subclinical metastatic SNs. Objectives: Intra-arterial chemoradiotherapy has been reported to be effective against not only primary tumors but also nodal metastases. We considered the hypothesis that intra-arterially injected cisplatin passed via lymph flow into regional nodes. This study aimed to investigate intra-arterially injected cisplatin distribution to regional nodes by comparing platinum concentrations in SNs and NSNs. Methods: Five patients with T1-2 N0 tongue cancer were treated with preoperative intra-arterial chemotherapy (cisplatin, 100 mg/m2) targeting primary cancer. Partial glossectomy together with SN biopsy and elective neck dissection were performed 2 weeks after intra-arterial chemotherapy. Platinum concentrations in the lymph nodes were measured using a Zeeman atomic absorption spectrometer. Results: Thirteen SNs were harvested together with eight NSNs from the areas adjacent to the SNs. Platinum concentrations were then measured, revealing a significant difference in platinum concentration between the SNs and the NSNs (mean ± SD, 0.682 ± 0.246 µg/g vs 0.506 ± 0.274 µg/g; p = 0.049).
Rights: Copyright (c) Informa
Type: article (author version)
URI: http://hdl.handle.net/2115/57077
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂下 智博

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