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Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy

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Title: Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy
Authors: Sakashita, Tomohiro Browse this author →KAKEN DB
Homma, Akihiro Browse this author →KAKEN DB
Hatakeyama, Hiromitsu Browse this author →KAKEN DB
Kano, Satoshi Browse this author →KAKEN DB
Mizumachi, Takatsugu Browse this author
Furusawa, Jun Browse this author
Yoshida, Daisuke Browse this author
Fujima, Noriyuki Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Tsuchiya, Kazuhiko Browse this author →KAKEN DB
Yasuda, Koichi Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Suzuki, Fumiyuki Browse this author
Fukuda, Satoshi Browse this author →KAKEN DB
Keywords: Maxillary sinus cancer
Salvage surgery
Squamous cell carcinoma
Chemotherapy
Radiotherapy
Intra-arterial
Issue Date: Apr-2014
Publisher: Elsevier
Journal Title: The British journal of oral & maxillofacial surgery
Volume: 52
Issue: 4
Start Page: 323
End Page: 328
Publisher DOI: 10.1016/j.bjoms.2014.01.018
PMID: 24582012
Abstract: Our aim was to evaluate the feasibility of salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy. We retrospectively analysed the records of 61 patients with cancer of the maxillary sinus who were treated in this way. Chemotherapy comprised 100-120 mg/m(2) superselective intra-arterial infusions of cisplatin given a median of 4 times weekly (range 2-5). Concurrent radiotherapy was given in a median dose of 65 Gy (range 24-70 Gy). Persistent or recurrent cancer of the maxillary sinus was found in 17 patients, of whom 11 had salvage surgery. The disease was controlled in 8 of the 11, and 7 of the 11 survived with no evidence of disease. Their 5-year overall survival was 61%. Two of the 11 developed serious operative complications. Salvage surgery for patients with persistent or recurrent cancer of the maxillary sinus treated by superselective chemoradiotherapy is both safe and successful. Salvage surgery is a good option when this sort of persistent or recurrent cancer is followed up after the regimen of chemoradiotherapy described. (C) 2014 Elsevier Inc. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/57079
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 坂下 智博

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