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Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy

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Title: Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy
Authors: Mizukami, Tatsuzo Browse this author
Kamachi, Hirofumi Browse this author →KAKEN DB
Mitsuhashi, Tomoko Browse this author →KAKEN DB
Tsuruga, Yosuke Browse this author
Hatanaka, Yutaka Browse this author →KAKEN DB
Kamiyama, Toshiya Browse this author →KAKEN DB
Matsuno, Yoshihiro Browse this author
Taketomi, Akinobu Browse this author →KAKEN DB
Keywords: Cancer stem cells
Neoadjuvant chemoradiotherapy
Pancreatic cancer
Issue Date: 21-Sep-2014
Publisher: Biomed Central
Journal Title: BMC Cancer
Volume: 14
Start Page: 687
Publisher DOI: 10.1186/1471-2407-14-687
Abstract: Background: Cancer stem cells (CSCs) have been reported to play an important role in chemoradiation resistance. Although the association of CSC markers with clinicopathological outcomes after neoadjuvant chemoradiotherapy (NACRT) has been reported in various types of cancers, there have been no such reports for pancreatic cancer. Here we examined the sequential changes in CSC marker expressions after NACRT in patients with pancreatic adenocarcinoma (PA) and the impact of these changes on the prognosis. Methods: We used immunohistochemistry to evaluate the expressions of the CSC markers epithelial cell adhesion molecule (EpCAM), CD24, CD44, CD133, CXCR4 and Aldehyde dehydrogenase 1 (ALDH1) in resected specimens obtained from 28 PA patients, and we compared these expressions with the patients' clinicopathological parameters and survival data. Results: The expression frequencies of CD44 and ALDH1 were significantly higher in the NACRT group (n = 17) compared to the non-NACRT group (n = 11), but the CD133 expression was significantly lower in the NACRT group. In the NACRT group, the expression of CD133 was inversely correlated with that of ALDH1, and CD133 +/ALDH1-expression was associated with an unfavorable patient outcome. Conclusion: This is the first report showing that NACRT may influence the expression frequencies of CD44, CD133 and ALDH1 in PA patients. Moreover, CD133 and ALDH1 expressions may be useful predictors of prognosis in PA patients who have received NACRT.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 蒲池 浩文

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