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Volume 62 Number 4 >

Olfactory ensheathing cells (OECs) degrade neurocan in injured spinal cord by secreting matrix metalloproteinase-2 in a rat contusion model

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Please use this identifier to cite or link to this item:http://doi.org/10.14943/jjvr.62.4.151

Title: Olfactory ensheathing cells (OECs) degrade neurocan in injured spinal cord by secreting matrix metalloproteinase-2 in a rat contusion model
Authors: Yui, Sho Browse this author
Fujita, Naoki Browse this author
Chung, Cheng-Shu Browse this author
Morita, Maresuke Browse this author
Nishimura, Ryohei Browse this author →KAKEN DB
Keywords: matrix metalloproteinase-2
neurocan
olfactory ensheathing cells
regenerative medicine
spinal cord injury
Issue Date: Nov-2014
Publisher: Graduate School of Veterinary Medicine, Hokkaido University
Journal Title: Japanese Journal of Veterinary Research
Volume: 62
Issue: 4
Start Page: 151
End Page: 162
Abstract: The mechanism by which olfactory ensheathing cells (OECs) exert their potential to promote functional recovery after transplantation into spinal cord injury (SCI) tissue is not fully understood, but the relevance of matrix metalloproteinases (MMPs) has been suggested. We evaluated the expression of MMPs in OECs in vitro and the MMP secretion by OECs transplanted in injured spinal cord in vivo using a rat SCI model. We also evaluated the degradation of neurocan, which is one of the axon-inhibitory chondroitin sulfate proteoglycans, using SCI model rats. The in vitro results showed that MMP-2 was the dominant MMP expressed by OECs. The in vivo results revealed that transplanted OECs secreted MMP-2 in injured spinal cord and that the expression of neurocan was significantly decreased by the transplantation of OECs. These results suggest that OECs transplanted into injured spinal cord degraded neurocan by secreting MMP-2.
Type: bulletin (article)
URI: http://hdl.handle.net/2115/57504
Appears in Collections:Japanese Journal of Veterinary Research > Volume 62 Number 4

Submitter: 獣医学部図書室

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