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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
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Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis
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| Title: | Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis |
| Authors: | Tamura, Yu Browse this author | | Ohta, Hiroshi Browse this author →KAKEN DB | | Yokoyama, Nozomu Browse this author | | Lim, Sue Yee Browse this author | | Osuga, Tatsuyuki Browse this author | | Morishita, Keitaro Browse this author →KAKEN DB | | Nakamura, Kensuke Browse this author | | Yamasaki, Masahiro Browse this author →KAKEN DB | | Takiguchi, Mitsuyoshi Browse this author →KAKEN DB |
| Keywords: | canine | | colon | | cytokine | | lymphocytic-plasmacytic colitis | | mRNA |
| Issue Date: | Oct-2014 |
| Publisher: | Japanese Society of Veterinary Science |
| Journal Title: | Journal of Veterinary Medical Science |
| Volume: | 76 |
| Issue: | 10 |
| Start Page: | 1407 |
| End Page: | 1410 |
| Publisher DOI: | 10.1292/jvms.13-0635 |
| Abstract: | Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-gamma, IL-4, IL-17 and IL-10 and pro-inflammatory cytokines, such as IL-1 beta, IL-6, TNF-alpha., IL-8, IL-12 and IL-23, in colonic mucosa from LPC dogs by quantitative real-time RT-PCR. No significant differences were detected in cytokine mRNA expressions between dogs with LPC and controls, except for IL-23p19. Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/57535 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 滝口 満喜
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