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Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis

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Title: Evaluation of Selected Cytokine Gene Expression in Colonic Mucosa from Dogs with Idiopathic Lymphocytic-plasmacytic Colitis
Authors: Tamura, Yu Browse this author
Ohta, Hiroshi Browse this author →KAKEN DB
Yokoyama, Nozomu Browse this author
Lim, Sue Yee Browse this author
Osuga, Tatsuyuki Browse this author
Morishita, Keitaro Browse this author →KAKEN DB
Nakamura, Kensuke Browse this author
Yamasaki, Masahiro Browse this author →KAKEN DB
Takiguchi, Mitsuyoshi Browse this author →KAKEN DB
Keywords: canine
colon
cytokine
lymphocytic-plasmacytic colitis
mRNA
Issue Date: Oct-2014
Publisher: Japanese Society of Veterinary Science
Journal Title: Journal of Veterinary Medical Science
Volume: 76
Issue: 10
Start Page: 1407
End Page: 1410
Publisher DOI: 10.1292/jvms.13-0635
Abstract: Lymphocytic-plasmacytic colitis (LPC) is a common form of inflammatory bowel disease (IBD) affecting the canine large intestine. Cytokines are thought to be involved in the pathogenesis of IBD. However, to date, few studies have investigated cytokine mRNA expression in dogs with LPC. In this study, we investigated mRNA transcription levels of T helper cell cytokines, such as IFN-gamma, IL-4, IL-17 and IL-10 and pro-inflammatory cytokines, such as IL-1 beta, IL-6, TNF-alpha., IL-8, IL-12 and IL-23, in colonic mucosa from LPC dogs by quantitative real-time RT-PCR. No significant differences were detected in cytokine mRNA expressions between dogs with LPC and controls, except for IL-23p19. Dogs with LPC failed to express a predominant cytokine profile in inflamed colonic mucosa as opposed to human IBD.
Rights: http://creativecommons.org/licenses/by-nc-nd/3.0/
Type: article
URI: http://hdl.handle.net/2115/57535
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 滝口 満喜

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