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Prognostic Value of Left Atrial Function in Dogs with Chronic Mitral Valvular Heart Disease

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Title: Prognostic Value of Left Atrial Function in Dogs with Chronic Mitral Valvular Heart Disease
Authors: Nakamura, K. Browse this author
Osuga, T. Browse this author
Morishita, K. Browse this author
Suzuki, S. Browse this author
Morita, T. Browse this author
Yokoyama, N. Browse this author
Ohta, H. Browse this author →KAKEN DB
Yamasaki, M. Browse this author →KAKEN DB
Takiguchi, M. Browse this author →KAKEN DB
Keywords: Cardiac-related death
Left atrial emptying fraction
Issue Date: Nov-2014
Publisher: Wiley-Blackwell
Journal Title: Journal of veterinary internal medicine
Volume: 28
Issue: 6
Start Page: 1746
End Page: 1752
Publisher DOI: 10.1111/jvim.12441
Abstract: Background: A strong correlation between left atrial (LA) dysfunction and the severity of cardiac disease has been described in human patients with various cardiac diseases. The role of LA dysfunction in dogs with chronic mitral valvular heart disease (CMVHD) has not been addressed. Objectives: To investigate the correlation between LA function and the prognosis of dogs with CMVHD. Animals: Thirty-eight client-owned dogs with CMVHD. Methods: Prospective clinical cohort study. Dogs were divided into 2 groups (survivors and nonsurvivors) based on the onset of cardiac-related death within 1year. Physical examination and echocardiographic variables were compared between the groups. For the assessment of the comparative accuracy in identifying patients with cardiac-related death, receiver operating characteristic (ROC) curves and multivariate logistic analysis were used. Results: The highest accuracy was obtained for the LA active fractional area change (LA-FAC(act)), with an area under the ROC curve (AUC) of 0.95, followed by the left atrial to aortic root ratio (LA/Ao), with an AUC of 0.94; peak early diastolic mitral inflow velocity (E), with an AUC of 0.85; and LA total fractional area change (LA-FAC(total)), with an AUC of 0.85. In the multivariate logistic regression analysis, LA-FAC(act) emerged as the only independent correlate of cardiac-related death within 1year (odds ratio=1.401, P=.002). Conclusions and Clinical Importance: Regarding both the size and function, the LA has a strong correlation with the prognosis of dogs with CMVHD. The most significant independent predictor of mortality in this study was LA-FAC(act).
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 滝口 満喜

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