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The Impact of Atherosclerotic Factors on Cerebral Aneurysm Is Location Dependent : Aneurysms in Stroke Patients and Healthy Controls

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Title: The Impact of Atherosclerotic Factors on Cerebral Aneurysm Is Location Dependent : Aneurysms in Stroke Patients and Healthy Controls
Authors: Hokari, Masaaki Browse this author
Isobe, Masanori Browse this author
Imai, Tetsuaki Browse this author
Chiba, Yasuhiro Browse this author
Iwamoto, Naotaka Browse this author
Isu, Toyohiko Browse this author
Keywords: Cerebral aneurysms
atherosclerotic factor
Issue Date: Oct-2014
Publisher: Elsevier
Journal Title: Journal of stroke & cerebrovascular diseases
Volume: 23
Issue: 9
Start Page: 2301
End Page: 2307
Publisher DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.019
Abstract: Previous studies have indicated that cerebrovascular diseases (CVDs) seem to increase the occurrence of unruptured intracranial aneurysms (UIAs). However, this maybe explained by the fact that CVDs and UIAs share common risk factors, such as hypertension (HT) and smoking. To clarify the impact of atherosclerotic risk factors on cerebral aneurysmal formation, we explored the incidence of UIAs and their locations in healthy controls and patients with CVD, who frequently have atherosclerotic risk factors. This study included consecutive 283 asymptomatic healthy adults and 173 acute stroke patients, from patients diagnosed with acute cerebral hemorrhage or cerebral infarction and admitted to our hospital. The incidence, maximum diameter, and location of UIAs were evaluated, and we also investigated the following factors: age, gender, current smoking, HT, diabetes mellitus (DM), and dyslipidemia. UIAs were found in 19 of the total 456 subjects (4.2%), 11 of 283 healthy subjects (3.9%), and 8 of 173 stroke patients (4.6%). These differences are not statically significant. The incidence of middle cerebral artery (MCA) aneurysms was significantly higher in the CVD patients than in the healthy controls (P = .03), and the incidence of paraclinoid aneurysms was significantly higher in the healthy controls than in the CVD patients (P = .03). Moreover, higher incidences of HTs and CVDs in the MCA aneurysms than in the other locations of UIAs were observed. These results indicate that the impact of atherosclerotic factors on cerebral aneurysmal formation depends on their location and that there is a stronger impact on MCA aneurysms than on paraclinoid aneurysms.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 穂刈 正昭

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