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Hokkaido University Collection of Scholarly and Academic Papers >
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A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide
| Title: | A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide |
| Authors: | Yuyama, Kohei Browse this author →KAKEN DB | | Sun, Hui Browse this author | | Usuki, Seigo Browse this author | | Sakai, Shota Browse this author | | Hanamatsu, Hisatoshi Browse this author | | Mioka, Tetsuo Browse this author | | Kimura, Nobuyuki Browse this author | | Okada, Megumi Browse this author | | Tahara, Hidetoshi Browse this author | | Furukawa, Jun-ichi Browse this author | | Fujitani, Naoki Browse this author →KAKEN DB | | Shinohara, Yasuro Browse this author | | Igarashi, Yasuyuki Browse this author →KAKEN DB |
| Keywords: | Exosome | | Amyloid-beta peptide | | Alzheimer's disease | | Cynomolgus monkey | | APP transgenic mouse | | Cerebrospinal fluid |
| Issue Date: | 2-Jan-2015 |
| Publisher: | Elsevier |
| Journal Title: | FEBS letters |
| Volume: | 589 |
| Issue: | 1 |
| Start Page: | 84 |
| End Page: | 88 |
| Publisher DOI: | 10.1016/j.febslet.2014.11.027 |
| PMID: | 25436414 |
| Abstract: | Elevated amyloid-beta peptide (A beta) in brain contributes to Alzheimer's disease (AD) pathogenesis. We demonstrated the presence of exosome-associated A beta in the cerebrospinal fluid (CSF) of cynomolgus monkeys and APP transgenic mice. The levels of exosome-associated A beta notably decreased in the CSF of aging animals. We also determined that neuronal exosomes, but not glial exosomes, had abundant glycosphingolipids and could capture A beta. Infusion of neuronal exosomes into brains of APP transgenic mice decreased A beta and amyloid depositions, similarly to what reported previously on neuroblastoma-derived exosomes. These findings highlight the role of neuronal exosomes in A beta clearance, and suggest that their downregulation might relate to Ab accumulation and, ultimately, the development of AD pathology. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57841 |
| Appears in Collections: | 生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 湯山 耕平
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