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A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide

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Title: A potential function for neuronal exosomes : Sequestering intracerebral amyloid-beta peptide
Authors: Yuyama, Kohei Browse this author →KAKEN DB
Sun, Hui Browse this author
Usuki, Seigo Browse this author
Sakai, Shota Browse this author
Hanamatsu, Hisatoshi Browse this author
Mioka, Tetsuo Browse this author
Kimura, Nobuyuki Browse this author
Okada, Megumi Browse this author
Tahara, Hidetoshi Browse this author
Furukawa, Jun-ichi Browse this author
Fujitani, Naoki Browse this author →KAKEN DB
Shinohara, Yasuro Browse this author
Igarashi, Yasuyuki Browse this author →KAKEN DB
Keywords: Exosome
Amyloid-beta peptide
Alzheimer's disease
Cynomolgus monkey
APP transgenic mouse
Cerebrospinal fluid
Issue Date: 2-Jan-2015
Publisher: Elsevier
Journal Title: FEBS letters
Volume: 589
Issue: 1
Start Page: 84
End Page: 88
Publisher DOI: 10.1016/j.febslet.2014.11.027
PMID: 25436414
Abstract: Elevated amyloid-beta peptide (A beta) in brain contributes to Alzheimer's disease (AD) pathogenesis. We demonstrated the presence of exosome-associated A beta in the cerebrospinal fluid (CSF) of cynomolgus monkeys and APP transgenic mice. The levels of exosome-associated A beta notably decreased in the CSF of aging animals. We also determined that neuronal exosomes, but not glial exosomes, had abundant glycosphingolipids and could capture A beta. Infusion of neuronal exosomes into brains of APP transgenic mice decreased A beta and amyloid depositions, similarly to what reported previously on neuroblastoma-derived exosomes. These findings highlight the role of neuronal exosomes in A beta clearance, and suggest that their downregulation might relate to Ab accumulation and, ultimately, the development of AD pathology. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Type: article (author version)
Appears in Collections:生命科学院・先端生命科学研究院 (Graduate School of Life Science / Faculty of Advanced Life Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 湯山 耕平

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