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Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma
| Title: | Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma |
| Authors: | Kato, Yasutaka Browse this author | | Nishihara, Hiroshi Browse this author →KAKEN DB | | Mohri, Hiromi Browse this author | | Kanno, Hiromi Browse this author | | Kobayashi, Hiroyuki Browse this author | | Kimura, Taichi Browse this author →KAKEN DB | | Tanino, Mishie Browse this author →KAKEN DB | | Terasaka, Shunsuke Browse this author →KAKEN DB | | Tanaka, Shinya Browse this author →KAKEN DB |
| Keywords: | Cyclooxygenase-2 | | Meningioma | | Immunohistochemistry | | Clinicopathological analysis |
| Issue Date: | Jan-2014 |
| Publisher: | Springer Japan |
| Journal Title: | Brain tumor pathology |
| Volume: | 31 |
| Issue: | 1 |
| Start Page: | 23 |
| End Page: | 30 |
| Publisher DOI: | 10.1007/s10014-012-0127-8 |
| PMID: | 23250387 |
| Abstract: | Tumorigenic activity of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the production of prostaglandins (PGs), has been proved for some types of cancer, including brain tumors. We evaluated expression of COX-2 in meningioma, one of the most common intracranial tumors in adults which accounts for 24-30 % of intracranial tumors. We performed immunostaining for COX-2 in 76 cases of meningioma consisting of 44 cases of low-grade (WHO Grade I) and 32 cases of high-grade (29 cases of Grade II and 3 cases of Grade III) meningioma, and evaluated COX-2 expression levels on the basis of staining intensity and proportion in tumor cells. The expression level of COX-2 in meningioma cells was significantly correlated with WHO grade (P = 0.0153). In addition, COX-2 expression was significantly correlated with MIB-1 labeling index for all 76 cases of meningioma (P = 0.0075), suggesting tumor promotion by COX-2 in meningioma progression. Our results may indicate the therapeutic value of non-steroidal anti-inflammatory drugs against meningioma, especially for patients with elevated proliferation, to regulate the tumorigenic activity of COX-2 in meningioma cells. |
| Rights: | The final publication is available at link.springer.com |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57872 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 西原 広史
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