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Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/57872

Title: Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma
Authors: Kato, Yasutaka Browse this author
Nishihara, Hiroshi Browse this author →KAKEN DB
Mohri, Hiromi Browse this author
Kanno, Hiromi Browse this author
Kobayashi, Hiroyuki Browse this author
Kimura, Taichi Browse this author →KAKEN DB
Tanino, Mishie Browse this author →KAKEN DB
Terasaka, Shunsuke Browse this author →KAKEN DB
Tanaka, Shinya Browse this author →KAKEN DB
Keywords: Cyclooxygenase-2
Meningioma
Immunohistochemistry
Clinicopathological analysis
Issue Date: Jan-2014
Publisher: Springer Japan
Journal Title: Brain tumor pathology
Volume: 31
Issue: 1
Start Page: 23
End Page: 30
Publisher DOI: 10.1007/s10014-012-0127-8
PMID: 23250387
Abstract: Tumorigenic activity of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the production of prostaglandins (PGs), has been proved for some types of cancer, including brain tumors. We evaluated expression of COX-2 in meningioma, one of the most common intracranial tumors in adults which accounts for 24-30 % of intracranial tumors. We performed immunostaining for COX-2 in 76 cases of meningioma consisting of 44 cases of low-grade (WHO Grade I) and 32 cases of high-grade (29 cases of Grade II and 3 cases of Grade III) meningioma, and evaluated COX-2 expression levels on the basis of staining intensity and proportion in tumor cells. The expression level of COX-2 in meningioma cells was significantly correlated with WHO grade (P = 0.0153). In addition, COX-2 expression was significantly correlated with MIB-1 labeling index for all 76 cases of meningioma (P = 0.0075), suggesting tumor promotion by COX-2 in meningioma progression. Our results may indicate the therapeutic value of non-steroidal anti-inflammatory drugs against meningioma, especially for patients with elevated proliferation, to regulate the tumorigenic activity of COX-2 in meningioma cells.
Rights: The final publication is available at link.springer.com
Type: article (author version)
URI: http://hdl.handle.net/2115/57872
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西原 広史

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