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Filamin acts as a key regulator in epithelial defence against transformed cells

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Title: Filamin acts as a key regulator in epithelial defence against transformed cells
Authors: Kajita, Mihoko Browse this author →KAKEN DB
Sugimura, Kaoru Browse this author →KAKEN DB
Ohoka, Atsuko Browse this author
Burden, Jemima Browse this author
Suganuma, Hitomi Browse this author
Ikegawa, Masaya Browse this author
Shimada, Takashi Browse this author
Kitamura, Tetsuya Browse this author →KAKEN DB
Shindoh, Masanobu Browse this author →KAKEN DB
Ishikawa, Susumu Browse this author
Yamamoto, Sayaka Browse this author
Saitoh, Sayaka Browse this author
Yako, Yuta Browse this author
Takahashi, Ryosuke Browse this author
Okajima, Takaharu Browse this author →KAKEN DB
Kikuta, Junichi Browse this author
Maijima, Yumiko Browse this author
Ishii, Masaru Browse this author →KAKEN DB
Tada, Masazumi Browse this author
Fujita, Yasuyuki Browse this author →KAKEN DB
Issue Date: Jul-2014
Publisher: Nature
Journal Title: Nature Communications
Volume: 5
Start Page: 4428
Publisher DOI: 10.1038/ncomms5428
PMID: 25079702
Abstract: Recent studies have shown that certain types of transformed cells are extruded from an epithelial monolayer. However, it is not known whether and how neighbouring normal cells play an active role in this process. In this study, we demonstrate that filamin A and vimentin accumulate in normal cells specifically at the interface with Src- or RasV12-transformed cells. Knockdown of filamin A or vimentin in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells. In addition, we show in zebrafish embryos that filamin plays a positive role in the elimination of the transformed cells. Furthermore, the Rho/Rho kinase pathway regulates filamin accumulation and filamin acts upstream of vimentin in the apical extrusion. This is the first report demonstrating that normal epithelial cells recognize and actively eliminate neighbouring transformed cells and that filamin is a key mediator in the interaction between normal and transformed epithelial cells.
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 藤田 恭之

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