| Title: | Filamin acts as a key regulator in epithelial defence against transformed cells |
| Authors: | Kajita, Mihoko Browse this author →KAKEN DB |
| Sugimura, Kaoru Browse this author →KAKEN DB |
| Ohoka, Atsuko Browse this author |
| Burden, Jemima Browse this author |
| Suganuma, Hitomi Browse this author |
| Ikegawa, Masaya Browse this author |
| Shimada, Takashi Browse this author |
| Kitamura, Tetsuya Browse this author →KAKEN DB |
| Shindoh, Masanobu Browse this author →KAKEN DB |
| Ishikawa, Susumu Browse this author |
| Yamamoto, Sayaka Browse this author |
| Saitoh, Sayaka Browse this author |
| Yako, Yuta Browse this author |
| Takahashi, Ryosuke Browse this author |
| Okajima, Takaharu Browse this author →KAKEN DB |
| Kikuta, Junichi Browse this author |
| Maijima, Yumiko Browse this author |
| Ishii, Masaru Browse this author →KAKEN DB |
| Tada, Masazumi Browse this author |
| Fujita, Yasuyuki Browse this author →KAKEN DB |
| Issue Date: | Jul-2014 |
| Publisher: | Nature |
| Journal Title: | Nature Communications |
| Volume: | 5 |
| Start Page: | 4428 |
| Publisher DOI: | 10.1038/ncomms5428 |
| PMID: | 25079702 |
| Abstract: | Recent studies have shown that certain types of transformed cells are extruded from an epithelial monolayer. However, it is not known whether and how neighbouring normal cells play an active role in this process. In this study, we demonstrate that filamin A and vimentin accumulate in normal cells specifically at the interface with Src- or RasV12-transformed cells. Knockdown of filamin A or vimentin in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells. In addition, we show in zebrafish embryos that filamin plays a positive role in the elimination of the transformed cells. Furthermore, the Rho/Rho kinase pathway regulates filamin accumulation and filamin acts upstream of vimentin in the apical extrusion. This is the first report demonstrating that normal epithelial cells recognize and actively eliminate neighbouring transformed cells and that filamin is a key mediator in the interaction between normal and transformed epithelial cells. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57876 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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