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Retrospective and prospective information coding by different neurons in the prefrontal cortex

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Title: Retrospective and prospective information coding by different neurons in the prefrontal cortex
Authors: Matsushima, Ayano Browse this author
Tanaka, Masaki Browse this author →KAKEN DB
Keywords: Prefrontal cortex
Working memory
Prediction
Single neurons
Primate
Issue Date: 23-Jan-2013
Publisher: Lippincott Williams & Wilkins
Journal Title: Neuroreport
Volume: 24
Issue: 2
Start Page: 73
End Page: 78
Publisher DOI: 10.1097/WNR.0b013e32835c8d66
PMID: 23269282
Abstract: Neurons in the lateral prefrontal cortex show sustained activity during the maintenance of visual memory. Previous studies have also indicated that prefrontal neurons show predictive activity in anticipation of upcoming visual stimuli. Because these retrospective and prospective coding of visual stimuli have been examined in separate experiments, how these processes interact in individual neurons remains unknown. To examine this, we recorded from single prefrontal neurons while monkeys performed two behavioural tasks. In one task, the animals passively viewed a moving object during fixation, whereas in the other, they remembered the location of a briefly presented visual cue for subsequent saccades. We found that many neurons were reactive and responded only after the visual stimulus appeared in their receptive field, while some neurons were predictive and increased their activity even before the moving stimulus entered the receptive field. In the memory-guided saccade trials, the reactive neurons exhibited sustained activity during the delay period, whereas the predictive neurons did not. Delays of visual response to a moving stimulus did not correlate with visual latency for a stationary stimulus. Instead, it correlated with the magnitude of sustained activity during the delay period in the memory-guided saccade task. Our data show that retrospective and prospective coding of visual information are represented by distinct neuronal populations, and that their temporal preferences are stable across different task conditions. Reactive signals may reflect the amount of temporal integration in short-term memory, whereas predictive signals may solely represent future events in isolation from the maintenance of past information.
Rights: This is a non-final version of an article published in final form in [Matsushima, Ayano; Tanaka, Masaki. Retrospective and prospective information coding by different neurons in the prefrontal cortex. Neuroreport. 24(2):73-78, January 23, 2013].
Relation: http://journals.lww.com/neuroreport/pages/default.aspx
Type: article (author version)
URI: http://hdl.handle.net/2115/57881
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 田中 真樹

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