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Suprabasin as a novel tumor endothelial cell marker
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| Title: | Suprabasin as a novel tumor endothelial cell marker |
| Authors: | Alam, Mohammad T. Browse this author | | Nagao-Kitamoto, Hiroko Browse this author | | Ohga, Noritaka Browse this author →KAKEN DB | | Akiyama, Kosuke Browse this author →KAKEN DB | | Maishi, Nako Browse this author →KAKEN DB | | Kawamoto, Taisuke Browse this author | | Shinohara, Nobuo Browse this author →KAKEN DB | | Taketomi, Akinobu Browse this author →KAKEN DB | | Shindoh, Masanobu Browse this author →KAKEN DB | | Hida, Yasuhiro Browse this author →KAKEN DB | | Hida, Kyoko Browse this author →KAKEN DB |
| Keywords: | Angiogenesis | | suprabasin | | suprabasin signaling | | tumor endothelial cell marker | | tumor endothelial cells |
| Issue Date: | Dec-2014 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Cancer science |
| Volume: | 105 |
| Issue: | 12 |
| Start Page: | 1533 |
| End Page: | 1540 |
| Publisher DOI: | 10.1111/cas.12549 |
| Abstract: | Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/57895 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 樋田 京子
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