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Suprabasin as a novel tumor endothelial cell marker

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Title: Suprabasin as a novel tumor endothelial cell marker
Authors: Alam, Mohammad T. Browse this author
Nagao-Kitamoto, Hiroko Browse this author
Ohga, Noritaka Browse this author →KAKEN DB
Akiyama, Kosuke Browse this author →KAKEN DB
Maishi, Nako Browse this author →KAKEN DB
Kawamoto, Taisuke Browse this author
Shinohara, Nobuo Browse this author →KAKEN DB
Taketomi, Akinobu Browse this author →KAKEN DB
Shindoh, Masanobu Browse this author →KAKEN DB
Hida, Yasuhiro Browse this author →KAKEN DB
Hida, Kyoko Browse this author →KAKEN DB
Keywords: Angiogenesis
suprabasin signaling
tumor endothelial cell marker
tumor endothelial cells
Issue Date: Dec-2014
Publisher: Wiley-Blackwell
Journal Title: Cancer science
Volume: 105
Issue: 12
Start Page: 1533
End Page: 1540
Publisher DOI: 10.1111/cas.12549
Abstract: Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.
Type: article
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 樋田 京子

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