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A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice
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| Title: | A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice |
| Authors: | Ishii, Akihiro Browse this author →KAKEN DB | | Ueno, Keisuke Browse this author →KAKEN DB | | Orba, Yasuko Browse this author →KAKEN DB | | Sasaki, Michihito Browse this author →KAKEN DB | | Moonga, Ladslav Browse this author | | Hang'ombe, Bernard M. Browse this author | | Mweene, Aaron S. Browse this author | | Umemura, Takashi Browse this author →KAKEN DB | | Ito, Kimihito Browse this author →KAKEN DB | | Hall, William W. Browse this author | | Sawa, Hirofumi Browse this author →KAKEN DB |
| Issue Date: | Dec-2014 |
| Publisher: | Nature Publishing Group |
| Journal Title: | Nature communications |
| Volume: | 5 |
| Start Page: | 5651 |
| Publisher DOI: | 10.1038/ncomms6651 |
| Abstract: | Bats can carry important zoonotic pathogens. Here we use a combination of next-generation sequencing and classical virus isolation methods to identify novel nairoviruses from bats captured from a cave in Zambia. This nairovirus infection is highly prevalent among giant leaf-nosed bats, Hipposideros gigas (detected in samples from 16 individuals out of 38). Whole-genome analysis of three viral isolates (11SB17, 11SB19 and 11SB23) reveals a typical bunyavirus tri-segmented genome. The strains form a single phylogenetic clade that is divergent from other known nairoviruses, and are hereafter designated as Leopards Hill virus (LPHV). When i.p. injected into mice, the 11SB17 strain causes only slight body weight loss, whereas 11SB23 produces acute and lethal disease closely resembling that observed with Crimean-Congo Haemorrhagic Fever virus in humans. We believe that our LPHV mouse model will be useful for research on the pathogenesis of nairoviral haemorrhagic disease. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/57925 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 石井 秋宏
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