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A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice

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Title: A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice
Authors: Ishii, Akihiro Browse this author →KAKEN DB
Ueno, Keisuke Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Sasaki, Michihito Browse this author →KAKEN DB
Moonga, Ladslav Browse this author
Hang'ombe, Bernard M. Browse this author
Mweene, Aaron S. Browse this author
Umemura, Takashi Browse this author →KAKEN DB
Ito, Kimihito Browse this author →KAKEN DB
Hall, William W. Browse this author
Sawa, Hirofumi Browse this author →KAKEN DB
Issue Date: Dec-2014
Publisher: Nature Publishing Group
Journal Title: Nature communications
Volume: 5
Start Page: 5651
Publisher DOI: 10.1038/ncomms6651
Abstract: Bats can carry important zoonotic pathogens. Here we use a combination of next-generation sequencing and classical virus isolation methods to identify novel nairoviruses from bats captured from a cave in Zambia. This nairovirus infection is highly prevalent among giant leaf-nosed bats, Hipposideros gigas (detected in samples from 16 individuals out of 38). Whole-genome analysis of three viral isolates (11SB17, 11SB19 and 11SB23) reveals a typical bunyavirus tri-segmented genome. The strains form a single phylogenetic clade that is divergent from other known nairoviruses, and are hereafter designated as Leopards Hill virus (LPHV). When i.p. injected into mice, the 11SB17 strain causes only slight body weight loss, whereas 11SB23 produces acute and lethal disease closely resembling that observed with Crimean-Congo Haemorrhagic Fever virus in humans. We believe that our LPHV mouse model will be useful for research on the pathogenesis of nairoviral haemorrhagic disease.
Type: article
Appears in Collections:人獣共通感染症リサーチセンター (Research Center for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石井 秋宏

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