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Temporary upregulation of anti-inflammatory cytokine IL-13 expression in the brains of CD14 deficient mice in the early stage of prion infection

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タイトル: Temporary upregulation of anti-inflammatory cytokine IL-13 expression in the brains of CD14 deficient mice in the early stage of prion infection
著者: Hasebe, Rie 著作を一覧する
Suzuki, Akio 著作を一覧する
Yamasaki, Takeshi 著作を一覧する
Horiuchi, Motohiro 著作を一覧する
キーワード: Prion disease
CD14
IL-13
Pathogenesis
発行日: 2014年11月 7日
出版者: Elsevier
誌名: Biochemical and biophysical research communications
巻: 454
号: 1
開始ページ: 125
終了ページ: 130
出版社 DOI: 10.1016/j.bbrc.2014.10.043
抄録: CD14 deficient (CD14(-/-)) mice survived longer than wild-type (WT) C57BL/6J mice when inoculated with prions intracerebrally, accompanied by increased expression of anti-inflammatory cytokine IL-10 by microglia in the early stage of infection. To assess the immune regulatory effects of CD14 in detail, we compared the gene expression of pro- and anti-inflammatory cytokines in the brains of WT and CD14(-/-) mice infected with the Chandler strain. Gene expression of the anti-inflammatory cytokine IL-13 in prion-infected CD14(-/-) mice was temporarily upregulated at 75 dpi, whereas IL-13 gene expression was not upregulated in prion-infected WT mice. Immunofluorescence staining showed that IL-13 was mainly expressed in neurons of the thalamus at 75 dpi. These results suggest that CD14 can suppress IL-13 expression in neurons during the early stage of prion infection. (C) 2014 Elsevier Inc. All rights reserved.
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/57931
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 長谷部 理絵

 

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