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Temporary upregulation of anti-inflammatory cytokine IL-13 expression in the brains of CD14 deficient mice in the early stage of prion infection

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Title: Temporary upregulation of anti-inflammatory cytokine IL-13 expression in the brains of CD14 deficient mice in the early stage of prion infection
Authors: Hasebe, Rie Browse this author →KAKEN DB
Suzuki, Akio Browse this author
Yamasaki, Takeshi Browse this author
Horiuchi, Motohiro Browse this author →KAKEN DB
Keywords: Prion disease
CD14
IL-13
Pathogenesis
Issue Date: 7-Nov-2014
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 454
Issue: 1
Start Page: 125
End Page: 130
Publisher DOI: 10.1016/j.bbrc.2014.10.043
PMID: 25450368
Abstract: CD14 deficient (CD14(-/-)) mice survived longer than wild-type (WT) C57BL/6J mice when inoculated with prions intracerebrally, accompanied by increased expression of anti-inflammatory cytokine IL-10 by microglia in the early stage of infection. To assess the immune regulatory effects of CD14 in detail, we compared the gene expression of pro- and anti-inflammatory cytokines in the brains of WT and CD14(-/-) mice infected with the Chandler strain. Gene expression of the anti-inflammatory cytokine IL-13 in prion-infected CD14(-/-) mice was temporarily upregulated at 75 dpi, whereas IL-13 gene expression was not upregulated in prion-infected WT mice. Immunofluorescence staining showed that IL-13 was mainly expressed in neurons of the thalamus at 75 dpi. These results suggest that CD14 can suppress IL-13 expression in neurons during the early stage of prion infection. (C) 2014 Elsevier Inc. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/57931
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 長谷部 理絵

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